5,140 results found
    1. Computational and Systems Biology

    Active contraction of microtubule networks

    Peter J Foster, Sebastian Fürthauer ... Daniel J Needleman
    Microtubule networks in frog egg extracts can spontaneously contract in a manner that can be quantitatively described by an active fluid model.
    1. Cell Biology
    2. Physics of Living Systems

    Centering and symmetry breaking in confined contracting actomyosin networks

    Niv Ierushalmi, Maya Malik-Garbi ... Kinneret Keren
    Novel mechanisms for cellular centering and symmetry breaking involving persistent contractile actomyosin flows and their hydrodynamic interactions with the fluid cytosol are presented and studied using a minimal, reconstituted system.
    1. Physics of Living Systems

    Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host–microbe associations

    Janna C Nawroth, Christoph Giez ... Thomas CG Bosch
    Spontaneous contractions allow shedding of the fluid boundary layer and thereby stabilize microbiota.
    1. Developmental Biology

    Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

    Swati Sharma, Richa Rikhy
    The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.
    1. Cell Biology

    Curvature-induced expulsion of actomyosin bundles during cytokinetic ring contraction

    Junqi Huang, Ting Gang Chew ... Mohan K Balasubramanian
    Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.
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    1. Cell Biology
    2. Developmental Biology

    Uncoupling apical constriction from tissue invagination

    SeYeon Chung, Sangjoon Kim, Deborah J Andrew
    Spatially coordinated apical constriction occurs during Drosophila salivary gland invagination, but the salivary gland can form fully internalized and elongated tubes even when this process is completely blocked.
    1. Cell Biology

    A novel checkpoint pathway controls actomyosin ring constriction trigger in fission yeast

    Tomás Edreira, Rubén Celador ... Yolanda Sánchez
    In fission yeast cell wall stress triggers a cytokinesis blockage specifically in the onset of actomyosin ring constriction.
    1. Cell Biology
    2. Computational and Systems Biology

    A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans

    Renat N Khaliullin, Rebecca A Green ... Karen Oegema
    Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

    Cameron Hill, Elisabetta Brunello ... Malcolm Irving
    The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.
    1. Cell Biology

    ATP activation of peritubular cells drives testicular sperm transport

    David Fleck, Lina Kenzler ... Marc Spehr
    Purinergic signaling controls mammalian sperm transport.

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