5,730 results found
    1. Cell Biology
    2. Developmental Biology

    Regulation of cell protrusions by small GTPases during fusion of the neural folds

    Ana Rolo, Dawn Savery ... Andrew J Copp
    The completion of neural tube closure requires small GTPase-regulated membrane protrusions from non-neural ectoderm cells at the tips of the neural folds.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The structure of the COPI coat determined within the cell

    Yury S Bykov, Miroslava Schaffer ... John AG Briggs
    Cryo-electron tomography of COPI vesicles in the Golgi reveals coat structure, disassembly dynamics, cargo binding, and morphological variability.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova, Patrick Aderhold ... John A G Briggs
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Independent amylase gene copy number bursts correlate with dietary preferences in mammals

    Petar Pajic, Pavlos Pavlidis ... Omer Gokcumen
    Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.
    1. Cancer Biology

    Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

    Brenton R Paolella, William J Gibson ... Rameen Beroukhim
    Partial copy loss of spliceosome genes are common non-driver gene dependencies in cancer.
    1. Cancer Biology

    Systematic identification of mutations and copy number alterations associated with cancer patient prognosis

    Joan C Smith, Jason M Sheltzer
    Gene copy number provides more prognostic information than gene mutation status in cancer.
    1. Cancer Biology
    2. Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus, Rajmohan Murali ... Charles L Sawyers
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

    Sebastià Franch-Expósito, Laia Bassaganyas ... Jordi Camps
    CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.
    1. Computational and Systems Biology

    A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

    Dina Cramer, Luis Serrano, Martin H Schaefer
    The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.
    1. Genetics and Genomics
    2. Medicine

    GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

    Michael Chong, Pedrum Mohammadi-Shemirani ... Guillaume Paré
    An ethnically robust pipeline for inferring mitochondrial DNA copy number from genotyping arrays was developed and applied to the UKBiobank, elucidating several common and rare loci in genes involved in the synthesis, maintenance, and organization of mitochondrial DNA.

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