63 results found
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

    Alexander R Leydon, Wei Wang ... Jennifer L Nemhauser
    The TPL corepressor binds to the core mediator complex through MED21 to inhibit transcription while simultaneously priming repressed genes for rapid reactivation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

    Ryo Nabeshima, Osamu Nishimura ... Hiroshi Hamada
    Fam60a, a component of the Sin3a complex, is required for embryonic development and regulates methylation at a subset of gene promoters.
    1. Chromosomes and Gene Expression

    ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes

    Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks
    The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

    Jerome C Nwachukwu, Sathish Srinivasan ... Kendall W Nettles
    Anti-inflammatory effects of resveratrol are mediated by the estrogen receptor to coordinate a complex array of transcriptional coregulators, suggesting that estrogenic effects must be considered in the complex polypharmacology of resveratrol.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

    David J Hosfield, Sandra Weber ... Sean W Fanning
    Effective antiestrogens engage a new structural interaction to improve therapeutic antagonism in hormone-resistant breast cancer cells expressing Y537S estrogen receptor alpha.
    1. Neuroscience

    Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice

    Laura Dean Heckman, Maria H Chahrour, Huda Y Zoghbi
    Transgenic mice with Rett-causing mutations in MeCP2 reveal that a basic cluster in the C-terminus of the protein binds DNA and that both the methyl-CpG binding domain and the transcriptional repression domain are necessary to elicit toxicity in MECP2 duplication syndrome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the core NuRD repression complex provides insights into its interaction with chromatin

    Christopher J Millard, Niranjan Varma ... John WR Schwabe
    An extensive interface between the proteins RBBP4 and MTA1 defines the three-dimensional architecture of the core NuRD complex and determines the recruitment of the complex to chromatin.
    1. Developmental Biology
    2. Genetics and Genomics

    A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

    Joo Lee, Caitlin A Taylor ... Kang Shen
    First comprehensive genetic analysis of a Myt1 family protein reveals that neurogenesis requires direct repression of non-neuronal identities by the Myt1 family protein through MuvB co-repressor complex.
    1. Cancer Biology

    A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

    Song Liu, Sangeeta Kumari ... Hannelore V Heemers
    Coregulators mediate selective interactions between DNA-bound androgen receptor and other transcription factors, which control distinct prostate cancer biology, suggesting disruption of critical interactions in these complexes as a novel therapeutic strategy.
    1. Chromosomes and Gene Expression

    A high-resolution map of transcriptional repression

    Ziwei Liang, Karen E Brown ... Matthias Merkenschlager
    High resolution mapping of transcriptional repression reveals complex and interdependent mechanisms that underpin rapid transitions between transcriptional states.

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