13,379 results found
    1. Neuroscience

    Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex

    Kasra Manoocheri, Adam G Carter
    The prelimbic and infralimbic prefrontal cortex (PFC) process distinct inputs from rostral and caudal basolateral amygdala (BLA), which engage different populations of projection neurons, via both direct connections and polysynaptic activity within the local network.
    1. Neuroscience

    Hippocampal inputs engage CCK+ interneurons to mediate endocannabinoid-modulated feed-forward inhibition in the prefrontal cortex

    Xingchen Liu, Jordane Dimidschstein ... Adam G Carter
    Endocannabinoids modulate ventral hippocampal inputs to the infralimbic prefrontal cortex by dampening feed-forward inhibition mediated by cholecystokinin-expressing (CCK+) interneurons onto layer 5 intratelencephalic (IT) cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

    Hayley Porter, Yang Li ... Suzana Hadjur
    STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.
    1. Neuroscience

    Decision and navigation in mouse parietal cortex

    Michael Krumin, Julie J Lee ... Matteo Carandini
    When mice use vision to choose their trajectories, a large fraction of parietal cortex activity can be precisely predicted from navigational attributes such as spatial position and heading.
    1. Evolutionary Biology
    2. Neuroscience

    Recalibrating timing behavior via expected covariance between temporal cues

    Benjamin J De Corte, Rebecca R Della Valle, Matthew S Matell
    Rats act as if they expect that the delays associated with temporal cues will covary due to a common causal factor.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

    Matthew A Cottee, Nadine Muschalik ... Mark van Breugel
    Structural analyses of the centriole proteins CPAP and STIL identify domains that are critical for centriole formation and provide a structural explanation for a mutation that causes human microcephaly.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Local genetic context shapes the function of a gene regulatory network

    Anna Nagy-Staron, Kathrin Tomasek ... Calin C Guet
    The phenotype of a gene regulatory network depends both qualitatively and quantitatively on the local genetic context of its individual components and cannot necessarily be predicted solely from network's topology.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

    Marion Portes, Thomas Mangeat ... Renaud Poincloux
    Cutting-edge super-resolution microscopy methods reveal the architecture and dynamics of the sealing zone formed by human osteoclasts and composed of coordinated groups of podosomal cores encircled by adhesion complexes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

    Samuel E Lacey, Shaoda He ... Andrew P Carter
    Relion was used to solve structures of microtubules decorated with dynein microtubule-binding domains revealing that an axonemal dynein distorts the microtubule cross-sectional curvature.
    1. Ecology
    2. Immunology and Inflammation

    Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

    Charlotte E Davies, Jessica E Thomas ... Christopher J Coates
    Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.

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