Population cortical recordings and computational network modeling support a novel mechanism underlying spontaneous UP-DOWN dynamics consisting on non-rhythmic transitions between a silent attractor and a low-rate inhibition-stabilized attractor.
Viktor J Olah, Annie M Goettemoeller ... Matthew JM Rowan
Electrophysiological and genetic analyses reveal a biophysical mechanism in parvalbumin interneurons, uncoupled from changes in gene expression, resulting in reduced cortical inhibition in early-stage Alzheimer's disease.
Rupali Ugrankar-Banerjee, Son Tran ... W Mike Henne
Fat-body-specific loss of actin isoform Act5C disrupts fat body cell growth and fat storage, lipoprotein secretion, and insulin signaling, revealing a non-canonical role for the cortical actin cytoskeleton in nutrient signaling and inter-organelle trafficking.
Dongsheng Xiao, Matthieu P Vanni ... Timothy H Murphy
Mesoscale cortical calcium activity correlating with single cortical and thalamic cell spiking reveal rich dynamics and support a novel approach for investigating in vivo functional networks in the mammalian brain.
Carsen Stringer, Marius Pachitariu ... Nicholas A Lesica
A new cortical network model fit directly to multi-neuron recordings reveals that local inhibitory feedback can control neural dynamics, modulate brain state and enhance sensory processing.
Isabelle Arnoux, Michael Willam ... Albrecht Stroh
In a premanifest mouse model of Huntington's disease at a stage very far from disease onset, significant network and behavior dysregulation was found, being rebalanced by treatment with metformin.
Central thalamus relay neurons dynamically switch the activity of cortical and subcortical networks at distinct frequencies, providing a mechanism for this region's role in arousal regulation.
Juan Luis Riquelme, Mike Hemberger ... Julijana Gjorgjieva
Single-neuron spikes in a network model of the turtle cortex trigger reliable, yet flexible sequences of activity through a sparse backbone of strong synaptic connections.