A Cre-dependent reporter mouse line is generated, validated, and used to map cell-type-specific proteome and phosphoproteome of corticostriatal projections across postnatal development.

The discovery of somatostatin-positive inhibitory neurons projecting from mouse cortex to striatum shows that corticostriatal pathways are not exclusively excitatory.

Recordings from the mouse brain as animals learn a lever pressing task reveal how the motor system optimizes skill learning by reducing variability in those aspects of task performance that are essential for achieving a goal.

The membrane nonlinearities of the dendritic arbor of striatal cholinergic interneurons conspire with the spatial distribution of its excitatory inputs to preferentially boost thalamic inputs.

Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.

Protein kinase A regulates the rapid, activity-dependent genesis of excitatory synapses during striatal development.

Analysis of slow wave brain state unravels the functional connectivity and the biological substrate of the rodent dorsolateral and dorsomedial striatum, demonstrating its organization in two non-overlapping circuits.

The molecular mechanisms beyond the bidirectionality (tTLP and tLTD) of endocanabinoid spike-timing dependent synaptic plasticity have been identified.

Patients with DYT1 dystonia show aberrant risk-aversion in a simple decision-making task, in accordance with predictions of a reinforcement learning model of corticostriatal trial-and-error learning.

The first comprehensive map of all excitatory inputs to the mouse striatum is presented and used to define and demarcate striatal subdivisions, including a previous unappreciated novel subdivision in the posterior striatum.