8,835 results found
    1. Cell Biology
    2. Plant Biology

    Stromule extension along microtubules coordinated with actin-mediated anchoring guides perinuclear chloroplast movement during innate immunity

    Amutha Sampath Kumar, Eunsook Park ... Jeffrey Lewis Caplan
    Stromules induced during plant innate immunity dynamically interact and use the cytoskeleton to form and to direct the movement of chloroplasts.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor

    Harriet Lane-Serff, Paula MacGregor ... Matthew K Higgins
    The structure of the trypanosome haptoglobin-haemoglobin receptor bound to its ligand reveals the molecular basis for ligand recognition in innate immunity and identifies molecular determinants that aid efficient uptake.
    1. Cancer Biology

    Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

    Teresa WM Fan, Richard M Higashi ... Andrew N Lane
    Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
    1. Evolutionary Biology

    Genome expansion in early eukaryotes drove the transition from lateral gene transfer to meiotic sex

    Marco Colnaghi, Nick Lane, Andrew Pomiankowski
    Lateral gene transfer is unable to resist mutation accumulation in large genomes, leading to selective pressure for the origin of meiotic sex in the first eukaryotes.
    1. Evolutionary Biology

    The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development

    Marco Colnaghi, Andrew Pomiankowski, Nick Lane
    Selective transfer of mitochondria in the Balbiani body ensures high-quality oocyte mitochondria at extreme ploidy, explaining many enigmatic features of female germline architecture including germ cell loss.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock

    Daniyal Tariq, Nicole Maurici ... Brian R Crane
    The intrinsic disorder of the circadian clock protein Frequency organizes binding partners, facilitates liquid–liquid phase separation, modulates Frequency phosphorylation, and derives from sequence properties conserved with homologous clock components.
    1. Genetics and Genomics

    Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories

    DeElegant Robinson, Michael Place ... Audrey P Gasch
    The genetic background of Saccharomyces cerevisiae yeast strains influences responses to gene overexpression.
    1. Cell Biology

    DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

    Matthew M Crane, Adam E Russell ... Matt Kaeberlein
    Activation of a DNA-damage cell cycle checkpoint during aging causes genome instability and senescence in yeast mother cells.
    1. Evolutionary Biology
    2. Plant Biology

    Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway

    Gaurav D Moghe, Bryan J Leong ... Robert L Last
    Integrative analysis of a specialized metabolic pathway across multiple non-model species illustrates mechanisms of emergence of chemical novelty in plant metabolism.
    1. Cell Biology

    Science Forum: Vision, challenges and opportunities for a Plant Cell Atlas

    Plant Cell Atlas Consortium, Suryatapa Ghosh Jha ... Seung Y Rhee
    A Plant Cell Atlas that shows the location and organization of molecules at cellular and tissue levels could have far-reaching consequences for plant sciences.

Refine your results by:

Type
Research categories