335 results found
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus, John P Incardona ... Sissel Jentoft
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Biochemistry and Chemical Biology

    Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

    Iti Kapoor, Philip Olivares, Satish K Nair
    Biochemical and structural biological analyses show how bacteria can recognize hormones that control the production of important secondary metabolites such as antiparasitics and antibiotics.
    1. Microbiology and Infectious Disease

    Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities

    Lisa Mahler, Sarah P Niehs ... Miriam A Rosenbaum
    This microscale cultivation strategy will help in the discovery of novel bacterial species and their prioritization for antibiotic screening campaigns.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal, Paola Nol Bernadino ... Emily P Balskus
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson, Susan Wyllie ... Alan H Fairlamb
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Symmetry breaking in reconstituted actin cortices

    Enas Abu Shah, Kinneret Keren
    A reconstituted system has been developed that self-organizes into dynamic actin cortices capable of spontaneous polarization, similar to the initial cortical polarization observed in cells during embryogenesis and development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Chemical and structural investigation of the paroxetine-human serotonin transporter complex

    Jonathan A Coleman, Vikas Navratna ... Eric Gouaux
    Structural and biochemical analysis of the mechanism of paroxetine binding to the serotonin transporter provides a framework for transporter inhibition and design of small-molecule inhibitors.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

    Zoe A Stephenson, Robert F Harvey ... Anne E Willis
    A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.
    1. Cell Biology

    TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

    António JM Santos, Ishier Raote ... Vivek Malhotra
    Building on previous work (Nogueira et al., 2014), we describe a mechanism for the generation of a mega-carrier for the export of bulky procollagen from the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

    Luca Costantino, Stefania Ferrari ... Maria Paola Costi
    The dimer destabilizers cause a dimer-to-monomer equilibrium shift favoring the human thymidylate synthase monomer more degradable by the proteasome, thus breaking the long-standing link between inhibition and enhanced expression of the protein to fight cancer drug resistance.

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