880 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

    Pengfei Xu, Haoze V Yu ... J Gage Crump
    Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.
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    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    Gill developmental program in the teleost mandibular arch

    Mathi Thiruppathy, Peter Fabian ... J Gage Crump
    Lineage tracing and genetic analysis in zebrafish show that the pseudobranch is a serial homolog of the gills arising from the jaw-forming mandibular arch, thus supporting the model that vertebrate jaws derived from an ancestral mandibular gill.
    1. Developmental Biology

    Ancient origin of lubricated joints in bony vertebrates

    Amjad Askary, Joanna Smeeton ... J Gage Crump
    Zebrafish have lubricated joints similar to ours and are a tractable model for arthritis research.
    1. Cell Biology
    2. Developmental Biology

    A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT

    Alexandre Francou, Kathryn V Anderson, Anna-Katerina Hadjantonakis
    High-resolution live and fixed tissue imaging combined with cell and tissue scale data analyses revealed that a ratchet-like constriction of the apical surfaces of cells drives the first step of an epithelial-to-mesenchymal transition taking place during mouse gastrulation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome

    Camilla S Teng, Man-chun Ting ... J Gage Crump
    Sequential live imaging of abnormal skull bone fusion in zebrafish reveals a deeply conserved role of two transcription factors, Twist1 and Tcf12, in regulating stem cell activity during growth of the skull.
    1. Cell Biology

    Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila

    Johanna Lattner, Weihua Leng ... David Flores-Benitez
    The polarity protein crumbs controls apical secretion and the architecture of the apical domain by modulating PI(4,5)P2 levels and the organization of apical Rab6-, Rab11-, and Rab30-dependent trafficking.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones

    Dion Giovannone, Sandeep Paul ... J Gage Crump
    Cartilage cells transition through a proliferative intermediate to give rise to bone and marrow fat cells in long bones.
    1. Developmental Biology

    Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex

    Cornelia Biehler, Katheryn E Rothenberg ... Patrick Laprise
    Cell biology analyses in Drosophila epithelial tissues reveal novel mechanisms connecting epithelial polarity proteins with Myosin-dependent cell contractility.
    1. Medicine

    Meta-research: justifying career disruption in funding applications, a survey of Australian researchers

    Adrian Barnett, Katie Page ... Susanna Cramb
    A survey of health and medical researchers revealed important diffrences in how career disruption is treated in funding decisions, with differences in what applicants with disruption are willing to divulge and the adjustments made by reviewers.

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