Blood cell transdifferentiation in Drosophila generates larval crystal cells through Notch-dependent signaling.

Single-cell RNA sequencing of Drosophila hemocytes in blood distinguishes various states within known blood cell types and implicates a novel role for fibroblast growth factor receptor signaling in inter-hemocyte crosstalk.

The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.

Insect symbiotic bacteria regulate expression of an odorant binding protein that mediates an evolutionarily conserved hematopoietic pathway crucial for host immune system development and function.

Effective antiestrogens engage a new structural interaction to improve therapeutic antagonism in hormone-resistant breast cancer cells expressing Y537S estrogen receptor alpha.

Bidirectional communication between hepatocytes and sinusoids governs long-range liquid-crystal order of hepatocyte polarity.

Crystal structural analysis reveals a novel reversible pan-inhibitor of TEA domains with enhanced potency adopts a unique binding mode.

AMDHD2 restricts the activity of the essential hexosamine pathway in mouse embryonic stem cells where GFPT2/GFAT2 instead of the common paralog GFPT1/GFAT1 controls metabolite entry.

The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.

Crystal structures of synaptic recognition molecules Sidekick-1 and -2 reveal a single homodimer interaction mode responsible for both cell-cell recognition and cis-clustering, suggesting that competition between cis and trans interactions may be critical to specificity.