989 results found
    1. Evolutionary Biology

    Microstructural and crystallographic evolution of palaeognath (Aves) eggshells

    Seung Choi, Mark E Hauber ... David J Varricchio
    The eggshells of palaeognath birds (e.g. ostrich, moa, kiwi, emu) have diverse homology and convergent features, and are useful modern analogues for the evolution of non-avian dinosaur eggshells.
    1. Structural Biology and Molecular Biophysics

    Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

    Kazumasa Oda, Takashi Nomura ... Osamu Nureki
    Time-resolved serial femtosecond crystallography revealed retinal kink and early changes in channelrhodopsin, which leads to the ion pore formation.
    1. Structural Biology and Molecular Biophysics

    Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

    Alberto Borsatto, Obaeda Akkad ... Francesco Luigi Gervasio
    A combination of simulations and experiments was used to discover druggable cryptic pockets in non-structural protein 1, a promising but difficult target for coronaviruses, indicating a viable drug discovery approach for otherwise undruggable targets.
    1. Structural Biology and Molecular Biophysics

    Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

    Tamar Skaist Mehlman, Justin T Biel ... Daniel A Keedy
    Many small-molecule fragments bind differently to the allosteric protein PTP1B in room-temperature instead of cryogenic crystal structures, which may be relevant for structure-based drug design.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-dimensional electron crystallography of protein microcrystals

    Dan Shi, Brent L Nannenga ... Tamir Gonen
    A new electron diffraction technique called MicroED allows protein structures to be determined from three-dimensional microcrystals.
    1. Structural Biology and Molecular Biophysics

    Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    Monarin Uervirojnangkoorn, Oliver B Zeldin ... William I Weis
    Post-refinement methods enable the use of X-ray free electron lasers for biological crystallography of systems in which sample quantity is a limitation.
    1. Structural Biology and Molecular Biophysics

    Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

    Daniel A Keedy, Lillian R Kenner ... James S Fraser
    The conformations of the enzyme cyclophilin A that are essential for its catalytic activity are temperature dependent and exhibit diverse responses, which is consistent with a complex energy landscape.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography

    Juliane John, Oskar Aurelius ... Martin Högbom
    The flavoprotein NrdI in class Ib ribonucleotide reductase controls superoxide generation and metal site oxidation by tuning the redox properties of its flavin cofactor via steric strain induced by the formation of the R2b–NrdI protein complex.
    1. Structural Biology and Molecular Biophysics

    An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

    Daniel A Keedy, Zachary B Hill ... James S Fraser
    By measuring how multiple conformations shift in response to temperature, a new allosteric binding site is discovered for the phosphatase PTP1B.
    1. Structural Biology and Molecular Biophysics

    The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

    Elin Claesson, Weixiao Yuan Wahlgren ... Sebastian Westenhoff
    Time-resolved crystallography provides insight into the photochemical reactions in photoreceptor proteins, explaining the earliest steps of how plants, fungi and bacteria sense red light.

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