Casein kinase 1G2 interacts with and inhibits the activation of receptor-interacting kinase 3, RIP3, in response to TNF and toll-like receptor family members and attenuates its necroptosis signaling activity.

Salt-inducible kinase 3 (SIK3) is an essential component of the mammalian circadian clock machinery, which governs robust circadian behavioral and other rhythms by destabilization of a core clock protein PER2 in a phosphorylation-dependent manner.

Thalidomide and its derivates induce degradation of many C₂H₂ zinc-finger transcription factors, including SALL4, providing insight into a long-standing mystery in modern pharmacology, and starting points for future drug development.

A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.

NIFK promotes lung cancer metastasis via Runx1-dependent repression of CK1α, which activates TCF4/β-catenin signaling.

A missense mutation in the human Cryptochrome 2 (CRY2) gene leads to the condition of familial advanced sleep phase.

Zebrafish knockouts can be generated in a few hours directly from wild-type eggs and are suitable for studying continuous traits, including behaviour.

Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.

The central RNA interference protein, human Argonaute-2, releases its target following phosphorylation on a critical loop in the protein, freeing microRNA-bound Argonaute-2 to seek out and repress additional targets.

Four conserved ciliary localization signals in the Joubert syndrome-associated INPP5E phosphoinositide phosphatase control its ciliary accumulation.