Kirsty J McMillan, Paul J Banks ... Peter J Cullen
An unbiased proteomic approach identifies a new regulator of AMPA receptor trafficking providing additional insight into synaptic transmission and plasticity.
Margot Tirole, Marta Huelin Gorriz ... Daniel Bendor
Hippocampal place cells modulate their firing rate during replay events to reflect the increases, or decreases, in firing rate experienced between contexts during behavior.
Kira M Düsterwald, Christopher B Currin ... Joseph V Raimondo
Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
Mohsen Jamali, Jerome Carriot ... Kathleen E Cullen
Through different coding strategies, irregular and regular otolith afferents preferentially encode translational self-motion and changes in static head orientation relative to gravity.
Collin Yvès Ewald, John M Hourihan ... Nancy E Hynes
Genetic analysis reveals NADPH oxidase generated reactive oxygen species as signals to re-establish cellular homeostasis during aging via activating a transcriptional response.
Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.
Maria Katharina Eckstein, Sarah L Master ... Anne GE Collins
Context factors such as experimental task and model parameterization can significantly impact modeling results, such that across tasks, the same participants show different fitted parameter values, and parameters capture different cognitive processes across tasks.
Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert
Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.