191 results found
    1. Biochemistry and Chemical Biology

    The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

    Januka S Athukoralage, Shirley Graham ... Malcolm F White
    The dynamic interplay between type III CRISPR enzymes governs cyclic nucleotide levels and infection outcomes in virus-host conflict.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

    Veronica Teresa Ober, George Boniface Githure ... Michael Boshart
    A minimal subset of two to three residues in cyclic nucleotide binding (CNB) domains controls nucleoside vs. cyclic nucleotide specificity, repurposing PKA of certain pathogens for novel nucleoside signaling pathways or sensing.
    1. Cell Biology

    Controlling fertilization and cAMP signaling in sperm by optogenetics

    Vera Jansen, Luis Alvarez ... Dagmar Wachten
    Optogenetics is a non-invasive way to study cAMP signaling in sperm cells, which is able to control sperm motility and fertilization.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm

    Sylvia Fechner, Luis Alvarez ... U Benjamin Kaupp
    Zebrafish sperm display an unusual pathway for Ca2+ signalling.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

    Zachary F Hallberg, Chi Ho Chan ... Ming C Hammond
    A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An auto-inhibited state of protein kinase G and implications for selective activation

    Rajesh Sharma, Jeong Joo Kim ... Choel Kim
    The crystal structure of a mammalian protein kinase G reveals contacts between the regulatory and catalytic domains, indicates how cGMP binding alters domain conformations and thus domain:domain interactions, and informs a model for enzyme auto-inhibition and cooperative activation.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics underlying elementary ligand binding events in human pacemaking channels

    Marcel P Goldschen-Ohm, Vadim A Klenchin ... Baron Chanda
    Single-molecule resolution of cAMP binding to the ligand binding domain of pacemaking channels in zero-mode waveguides reveals the dynamics of the distinct steps underlying both binding and isomerization of the binding domain.
    1. Neuroscience

    Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

    Ely Contreras, Jacob D Bhoi ... Tiffany M Schmidt
    Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.
    1. Cell Biology
    2. Immunology and Inflammation

    The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

    Steven M Blaauboer, Samira Mansouri ... Lei Jin
    In mice, cyclic di-GMP is an effective mucosal pneumococcal vaccine adjuvant that stimulates the immune response via two distinct mechanisms.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways

    Alice L Herneisen, Zhu-Hong Li ... Sebastian Lourido
    Time-resolved phosphoproteomics and thermal proteome profiling reveal the Ca2+-responsive proteome of the model apicomplexan Taxoplasma gondii, identifying PP1 as a Ca2+-responsive enzyme that regulates Ca2+ uptake to promote parasite motility.

Refine your results by:

Type
Research categories