35 results found
    1. Stem Cells and Regenerative Medicine

    Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

    Hanh Thi-Kim Vu, Jochen C Rink ... Alejandro Sánchez Alvarado
    Planarians provide evidence for a common evolutionary origin of vertebrate and invertebrate excretory systems and provide a novel experimental model to study human kidney diseases.
    1. Developmental Biology

    Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Daniyal J Jafree, Dale Moulding ... David A Long
    Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.
    Short Report Updated
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    1. Cell Biology
    2. Developmental Biology

    Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse

    Yuanyuan Li, Wenyan Xu ... Zhaoxia Sun
    Genetic and chemical genetic analysis pinpoint defective epithelial cells as the driver for NPHP like phenotypes in Invs mutants, demonstrate genetic interaction between Invs and Ift88 and identify the HDAC inhibitor valproic acid as a suppressor for Invs mutant phenotypes.
    1. Cancer Biology

    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

    Alessia Calcagnì, Lotte kors ... Andrea Ballabio
    Kidney-specific TFEB overexpression in transgenic mice closely recapitulates features observed in both TFEB- and TFE3-mediated human kidney tumors.
    1. Stem Cells and Regenerative Medicine

    Cystic Kidney Disease: Planarian ‘kidneys’ go with the flow

    Melanie Issigonis, Phillip A Newmark
    Insight
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    1. Developmental Biology

    Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

    Jonghyeob Lee, Takuya Sugiyama ... Seung K Kim
    Cells from the human pancreatic duct can be grown in culture and triggered to become insulin-producing cells, which could potentially be transplanted into patients with diabetes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

    Xiaowen Liu, Thuy Vien ... David E Clapham
    The primary cilia polycystin proteins, polycystin-1 and polycystin-2, affect cilia length in the kidney collecting duct epithelia, but only polycystin-2 is required for the functional ion channel in this organelle.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

    Huachao Huang, Yinshan Fang ... Jianwen Que
    A population of p63+ Krt5- epithelial cells contribute to alveolar regeneration independent of the presence of ectopic tuft cells following viral infection.
    1. Developmental Biology
    2. Physics of Living Systems

    Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination

    Hanqing Guo, Michael Swan, Bing He
    Combined optogenetic and computer modeling approaches reveal how mechanical bistability of the mesoderm epithelium works jointly with apical constriction to facilitate mesoderm invagination in Drosophila, a well-characterized model for epithelial folding.
    1. Microbiology and Infectious Disease

    A dedicated diribonuclease resolves a key bottleneck for the terminal step of RNA degradation

    Soo-Kyoung Kim, Justin D Lormand ... Vincent T Lee
    RNA degradation is completed through specific intermediates, such as diribonucleotides, which must be removed from the cells by a specific enzyme.

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