58 results found
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

    Benjamin JM Taylor, Yee Ling Wu, Cristina Rada
    Transcribed promoters are highly susceptible to mutation by cytidine deaminases, implicating stable exposure of single stranded DNA structures, rather than cofactors, in localising mutation during tumourigenesis and antibody maturation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

    Weiwei Yang, Yu-Cheng Lin ... Laurence Ettwiller
    A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.
    1. Genetics and Genomics

    APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

    Sandra R Richardson, Iñigo Narvaiza ... John V Moran
    Combining in vitro and in vivo assays demonstrates that the cytidine deaminase APOBEC3A can inhibit LINE-1 retrotransposition by deaminating transiently exposed single-strand DNA that arises during the process of LINE-1 integration.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

    Marcos H de Moraes, FoSheng Hsu ... Joseph D Mougous
    Interbacterial interactions can promote mutagenesis, and possibly adaptation, when intoxicated cells survive exposure to type VI secretion-delivered DNA deaminase toxins.
    1. Chromosomes and Gene Expression

    DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

    Benjamin JM Taylor, Serena Nik-Zainal ... Michael S Neuberger
    Enzymes that remove amine groups from cytosine bases in DNA are likely involved in generating the clusters of mutations (kataegis) seen in breast cancer.
    1. Cell Biology
    2. Immunology and Inflammation

    Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

    Jean-Marie Buerstedde, Noel Lowndes, David G Schatz
    Intra- and intergenic deletions by repeat recombination broaden the mutagenic potential of the activation induced cytidine deaminase (AID) protein.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Repair of naturally occurring mismatches can induce mutations in flanking DNA

    Jia Chen, Brendan F Miller, Anthony V Furano
    The repair of spontaneous DNA damage can introduce mutators that lead to further genetic changes, which could underlie evolutionary change, disease and aging.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang, Michael Emerman ... Richard N McLaughlin Jnr
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.
    1. Structural Biology and Molecular Biophysics

    HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

    Michael Morse, M Nabuan Naufer ... Mark C Williams
    APOBEC3G, an anti-viral protein with the capability to inhibit HiV-1 infectivity, binds single stranded DNA in multiple physical conformations, enabling complex interactions that allow APOBEC3G to perform multiple diverse functions.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

    Samantha DM Arras, Nellie Sibaeva ... Anthony M Poole
    An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.

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