103 results found
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

    Ignacio Moraga, Jamie B Spangler ... K Christopher Garcia
    Synthetic cytokines engage new signaling programs with therapeutic potential.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Cell Signaling: Extraordinary effects of unnatural pairings

    Alejandro Villarino, John J O'Shea
    Engineered molecules based on human cytokines have potential uses in research and medicine.
    Insight
    Formats available:
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    1. Immunology and Inflammation

    Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

    Jonathan Martinez-Fabregas, Stephan Wilmes ... Ignacio Moraga
    Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming the antigen specificity of B cells using genome-editing technologies

    James E Voss, Alicia Gonzalez-Martin ... Dennis R Burton
    Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
    Short Report Updated
    Formats available:
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    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    De novo-designed transmembrane domains tune engineered receptor functions

    Assaf Elazar, Nicholas J Chandler ... Sarel J Fleishman
    Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

    Caleb R Glassman, Leon Su ... K Christopher Garcia
    A panel of interleukin-2 partial agonists designed to exploit distinct immune cell response thresholds enabled selective activation of regulatory T cells in vivo.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Structure of the IL-27 quaternary receptor signaling complex

    Nathanael A Caveney, Caleb R Glassman ... K Christopher Garcia
    The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.
    Short Report Updated
    Formats available:
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    • PDF
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

    Ryan D Ferrao, Heidi JA Wallweber, Patrick J Lupardus
    An intracellular cytokine receptor 'switch' motif is critical for the dimerization of JAK2 and activation of the JAK2 kinase.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The discriminatory power of the T cell receptor

    Johannes Pettmann, Anna Huhn ... Omer Dushek
    The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.
    1. Immunology and Inflammation

    A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

    Enas Abu-Shah, Philippos Demetriou ... Michael L Dustin
    The use of advanced 3D culture systems with engineered quiescent human T-cells, mimicking in vivo cellular dynamics, paves the way to a new era of much needed pre-clinical research tools.

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