Jonathan Martinez-Fabregas, Stephan Wilmes ... Ignacio Moraga
Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.
James E Voss, Alicia Gonzalez-Martin ... Dennis R Burton
Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
Assaf Elazar, Nicholas J Chandler ... Sarel J Fleishman
Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.
Caleb R Glassman, Leon Su ... K Christopher Garcia
A panel of interleukin-2 partial agonists designed to exploit distinct immune cell response thresholds enabled selective activation of regulatory T cells in vivo.
Nathanael A Caveney, Caleb R Glassman ... K Christopher Garcia
The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.
Enas Abu-Shah, Philippos Demetriou ... Michael L Dustin
The use of advanced 3D culture systems with engineered quiescent human T-cells, mimicking in vivo cellular dynamics, paves the way to a new era of much needed pre-clinical research tools.