Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.

Synthetic cytokines engage new signaling programs with therapeutic potential.

The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.

KinCytE is a web-based platform that explores kinase-cytokine-driven signaling and its relevance to understanding and treating diseases linked to disruptions in these pathways.

Immune activation in Drosophila macrophages during oxidative stress is regulated by DNA damage signaling, which controls proinflammatory cytokine release and the susceptibility of the fly to oxidative stress.

The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.

The GDF15 receptor, GFRAL,is expressed on a unique population of brainstem CCK neurons and mediates pathophysiological anorexia.

Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.

Bone marrow-derived macrophages reveal that leucine promotes M2 polarization through mTORC1/LXRα/Arg1 signaling pathway, establishing a fundamental link between metabolism and immunity.

A novel B cell receptor induced interleukin 10 (IL-10) production from B10 cells involves signal transducer and activator of transcription 5 (STAT5) mediated IL-6 production which induces IL-10 in an autocrine and paracrine fashion from B10 cells.