2,946 results found
    1. Cell Biology
    2. Computational and Systems Biology

    DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

    Xinxin Wang, Zhiming Chen ... Gaudenz Danuser
    A new user-intervention-free classification, using single-fluorescent markers, measures conventionally unmeasureable phenotypes in early stages during clathrin-mediated endocytosis.
    1. Neuroscience

    A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

    Wei Tang, Saad Jbabdi ... Suzanne N Haber
    A hub in the rostral anterior cingulate cortex receives unusually high and functionally diverse inputs, providing a biological interface between motivation, incentive based learning, and decision making.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere, Yuhki Saito ... Zhe Chen
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
    1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova
    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
    1. Biochemistry and Chemical Biology

    SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

    Pascal Demange, Etienne Joly ... Sébastien Britton
    Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.
    1. Neuroscience

    NOVA2-mediated RNA regulation is required for axonal pathfinding during development

    Yuhki Saito, Soledad Miranda-Rottmann ... Robert B Darnell
    The RNA-binding protein NOVA2 coordinately regulates the alternative splicing of key components in axon guidance and outgrowth pathways, with severe functional consequences.
    1. Developmental Biology
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li, Kevin M Collins ... Kang Shen
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Neuroscience

    Excitation and inhibition in anterior cingulate predict use of past experiences

    Jacqueline Scholl, Nils Kolling ... Matthew FS Rushworth
    Neurotransmitter balance in a region in frontal cortex controls how much people use information they have learnt to guide their behaviour.
    1. Developmental Biology
    2. Neuroscience

    Revisiting the role of Dcc in visual system development with a novel eye clearing method

    Robin J Vigouroux, Quénol Cesar ... Kim Tuyen Nguyen-Ba-Charvet
    A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
    1. Developmental Biology
    2. Neuroscience

    DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

    Laura Morcom, Ilan Gobius ... Linda J Richards
    Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.

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