181 results found
    1. Neuroscience

    Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans

    Zoë A Hilbert, Dennis H Kim
    A sexually dimorphic transcriptional switch in sensory neurons integrates information about microbial environment and nutritional state to regulate exploratory behavior in C. elegans..
    1. Neuroscience

    A gene-expression-based neural code for food abundance that modulates lifespan

    Eugeni V Entchev, Dhaval S Patel ... QueeLim Ch'ng
    TGFβ and serotonin signaling in a neural circuit encodes food availability; these signals regulate the dynamic range and variability on the circuit to impact coding accuracy and lifespan responses.
    1. Neuroscience

    PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans

    Zoë A Hilbert, Dennis H Kim
    Sex-specific neuropeptide signaling in the shared sensory nervous system regulates sexually dimorphic gene expression and male-specific behavior in C. elegans.
    1. Developmental Biology
    2. Neuroscience

    Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies

    Jodie A Schiffer, Francesco A Servello ... Javier Apfeld
    C. elegans nematodes use a sensory-neuronal circuit to determine whether to defend themselves from hydrogen peroxide attack or to freeload off orthologous protective defenses from bacteria in their surrounding environment.
    1. Computational and Systems Biology
    2. Neuroscience

    Genetic control of encoding strategy in a food-sensing neural circuit

    Giovanni Diana, Dhaval S Patel ... QueeLim Ch'ng
    Building on previous work (Entchev et al, 2015), computational analyses reveal that the choice between redundant versus synergistic encoding in a gene expression code for food abundance is controlled by cross-talk and auto-regulation among TGF-beta and serotonin pathways.
    1. Immunology and Inflammation
    2. Neuroscience

    Intestinal infection regulates behavior and learning via neuroendocrine signaling

    Jogender Singh, Alejandro Aballay
    Feedback from the intestine during infection can modulate the behavior, learning, and microbial perception of the host.
    1. Neuroscience

    Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior of C. elegans

    Sonia A Boor, Joshua D Meisel, Dennis H Kim
    Distinct interoceptive and gustatory bacterial food cues converge to control neuroendocrine gene expression in two neurons, which modulates and is correlated with internal states driving feeding versus foraging behavior.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Indole produced during dysbiosis mediates host–microorganism chemical communication

    Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou
    In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal, Asuka Takeishi ... Piali Sengupta
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans

    Meng Huang, Minjie Hong ... Xuezhu Feng
    The depletion of a new class of putative histone methyltransferases, including MET-2, SET-6, SET-19, SET-20, SET-21, SET-32, and SET-33, induced synergistic lifespan extension in daf-2 animals to an average lifespan nearly three times that of wild-type animals.

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