15,626 results found
  1. Scientific Publishing: Recognizing the importance of new tools and resources for research

    Randy Schekman, Detlef Weigel, Fiona M Watt
    eLife is introducing a new article type—called Tools and Resources—to highlight new experimental techniques, datasets, software tools and other resources.
    Editorial
    Formats available:
    • HTML
    • PDF
    1. Computational and Systems Biology

    Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

    Christopher P Mancuso, Hyunseok Lee ... Ahmad S Khalil
    Laboratory experiments using a microbial community and mathematical modeling reveal how environmental disturbances can predictably alter the diversity and composition of an ecosystem.
    1. Neuroscience

    Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq

    Angela R Wild, Peter W Hogg ... Shernaz X Bamji
    A curated resource to study the brain RNA expression patterns of the genes that regulate palmitoylation is presented, alongside a detailed exploration of how these patterns can inform future research.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience

    A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution

    Geoffrey W Meissner, Aljoscha Nern ... FlyLight Project Team
    Single neuron images of Drosophila driver lines reveal neuron shape and are searchable, enabling comparisons to electron microscopy and prediction of intersectional neuron targeting strategies.
    1. Structural Biology and Molecular Biophysics

    Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment

    James M Gibson, Heying Cui ... Chunyu Wang
    A cargo recognition α-helix was identified in Nup358, which is required for activation of a dynein-dependent transport pathway that is essential for brain development.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

    Camilo Barbosa, Roderich Römhild ... Hinrich Schulenburg
    Evolutionary trade-offs enhance efficacy of antibiotic therapy by constraining bacterial adaptation in dependence of drug order and trade-off effect size.
    1. Cell Biology
    2. Neuroscience

    Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells

    Andrea McQuate, Sharmon Knecht, David W Raible
    The highly metabolically active hair cells of the zebrafish lateral line have a distinct mitochondrial phenotype consisting of small mitochondria apically and large, networked mitochondrion basally, demonstrating a nonuniform mitochondrial architecture that is sculpted by cellular activity.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

    Laura M Doherty, Caitlin E Mills ... Peter K Sorger
    The integration of experimental and data mining approaches provides novel insights into deubiquitinating enzymes individually and as a gene family.
    1. Computational and Systems Biology

    Resource allocation accounts for the large variability of rate-yield phenotypes across bacterial strains

    Valentina Baldazzi, Delphine Ropers ... Hidde de Jong
    A coarse-grained model of microbial growth coupling fluxes of carbon and energy shows that resource allocation is a major explanatory factor of the observed variability of growth rates and growth yields across different bacterial strains.

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