1,747 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie, Cemalettin Bekpen ... Diethard Tautz
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Protein evidence of unannotated ORFs in Drosophila reveals diversity in the evolution and properties of young proteins

    Eric B Zheng, Li Zhao
    The analysis of mass-spectrometry data for all possible open reading frames reveals protein evidence for evolutionarily young, unannotated proteins with distinct characters.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Repeated origins, widespread gene flow, and allelic interactions of target-site herbicide resistance mutations

    Julia M Kreiner, George Sandler ... Stephen I Wright
    The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf, Olin K Silander, Erik van Nimwegen
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

    Nikolaos Vakirlis, Anne-Ruxandra Carvunis, Aoife McLysaght
    Homology information implicit in regions of conserved synteny allows quantification of gene origination by complete sequence divergence, revealing a larger-than-expected role for other mechanisms of origin, including de novo origination.
    1. Genetics and Genomics

    Fast turnover of genome transcription across evolutionary time exposes entire non-coding DNA to de novo gene emergence

    Rafik Neme, Diethard Tautz
    Deep sequencing of transcriptomes from closely related taxa shows that the whole genome can become subject to evolutionary testing within a short time frame via de novo evolution of genes.
    1. Evolutionary Biology

    Long non-coding RNAs as a source of new peptides

    Jorge Ruiz-Orera, Xavier Messeguer ... M Mar Alba
    Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila

    Evan Witt, Sigi Benjamin ... Li Zhao
    Single-cell RNA-sequencing and germline substitutions provide novel insights into how testis is a hotspot for evolutionary innovation of genes, expression, and mutation at the single-cell level.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Genetic Novelty: How new genes are born

    Urminder Singh, Eve Syrkin Wurtele
    Analysis of yeast, fly and human genomes suggests that sequence divergence is not the main source of orphan genes.
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    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

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