12,108 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

    Scott A Rankin, Jeffrey D Steimle ... Aaron M Zorn
    Epistatic analysis in Xenopus and mouse embryos reveals an evolutionarily conserved gene regulatory network downstream of the transcription factor Tbx5 and retinoic acid that coordinates cardiac and pulmonary development.
    1. Developmental Biology
    2. Neuroscience

    Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

    Lin Pan, Amelia Trimarco ... Ye Zhang
    Oligodendrocyte-lineage cells secrete L-type prostaglandin synthase in an autocrine loop to promote oligodendrocyte development and myelination.
    1. Neuroscience

    Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

    Michiel Vellema, Mariana Diales Rocha ... Manfred Gahr
    The ability to quickly re-acquire a previously lost motor skill is associated with lasting synaptic changes in the brain circuit that controls that motor skill.
    1. Developmental Biology
    2. Evolutionary Biology

    Developmental hourglass and heterochronic shifts in fin and limb development

    Koh Onimaru, Kaori Tatsumi ... Shigehiro Kuraku
    Omics approaches reveal conserved and diversified gene regulation between fin and limb development.
    1. Developmental Biology

    A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium

    Susan M Motch Perrine, M Kathleen Pitirri ... Joan T Richtsmeier
    Analysis of 3D reconstructions of chondrocrania of the FgfrcC342Y/+ Crouzon syndrome mouse show the direct effects of this Fgfr2 mutation on embryonic cranial cartilage formation and the indirect effects of chondrocranial morphology on cranial dermal bone development.
    1. Computational and Systems Biology
    2. Developmental Biology

    Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering

    Maria Abou Chakra, Ruth Isserlin ... Gary D Bader
    A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

    Renaud Mevel, Ivana Steiner ... Georges Lacaud
    The transcription factor RUNX1 marks a distinct lineage of luminal castration-resistant prostate cells established early during development and enriched in the periurethral region of adult mouse prostate.
    1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley
    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
    1. Neuroscience

    Prenatal development of neonatal vocalizations

    Darshana Z Narayanan, Daniel Y Takahashi ... Asif A Ghazanfar
    Vocal development in marmoset monkeys begins in utero.
    1. Developmental Biology

    Single nuclei RNA-seq of mouse placental labyrinth development

    Bryan Marsh, Robert Blelloch
    A time-course of single nuclei RNA-seq of the mouse placenta identifies trophoblast subtypes and the genes, signaling events, and transcriptional networks important for their differentiation, maintenance, and function.

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