2,509 results found
    1. Epidemiology and Global Health

    A user-friendly, open-source tool to project impact and cost of diagnostic tests for tuberculosis

    David W Dowdy, Jason R Andrews ... Robert H Gilman
    A freely available computer program that takes into account specific local conditions enables users to predict the impact of adopting different diagnostic strategies on the spread of tuberculosis in their region.
    1. Cancer Biology

    Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

    Kevin M Elias, Wojciech Fendler ... Dipanjan Chowdhury
    Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
    1. Medicine
    2. Microbiology and Infectious Disease

    Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

    Elin Näsström, Christopher M Parry ... Stephen Baker
    Mass spectrometry on plasma from patients with typhoid fever and other febrile disease identified and validated 24 metabolites that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.
    1. Microbiology and Infectious Disease

    High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

    Claudia A Vera-Arias, Aurel Holzschuh ... Cristian Koepfli
    A novel high-throughput method for Plasmodium falciparum genotyping will enable malaria control programs to make informed decisions about the best tool to use for the diagnosis of malaria.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    CriSNPr, a single interface for the curated and de novo design of gRNAs for CRISPR diagnostics using diverse Cas systems

    Asgar H Ansari, Manoj Kumar ... Debojyoti Chakraborty
    The web-server CriSNPr overcomes difficulties associated with the different CRISPR diagnostic platforms that stem from Cas-specific single guide RNA design parameters, thereby minimizing the time and effort required for individual assay design.
    1. Cancer Biology
    2. Medicine

    Tissue-derived exosome proteomics identifies promising diagnostic biomarkers for esophageal cancer

    Dingyu Rao, Hua Lu ... Zhixian Tang
    Exosomal CD54 can be used as an effective biomarker for esophageal squamous cell carcinoma and CD54 promotes the proliferation and migration of tumor cells in vitro.
    1. Epidemiology and Global Health

    FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

    Manoj Kumar, Sneha Gulati ... Debojyoti Chakraborty
    A newly developed lateral flow assay can diagnose mutational signatures of major SARS CoV-2 variants in a rapid, inexpensive, and sequence-free manner.
    1. Neuroscience

    Functional connectivity subtypes associate robustly with ASD diagnosis

    Sebastian GW Urchs, Angela Tam ... Pierre Bellec
    Unsupervised clustering of the heterogeneous functional brain organization in autism reveals generalizable patterns of connectivity alterations that extend to the general population.
    1. Medicine
    2. Microbiology and Infectious Disease

    Novel fast pathogen diagnosis method for severe pneumonia patients in the intensive care unit: randomized clinical trial

    Yan Wang, Xiaohui Liang ... Wenkui Yu
    A novel species-specific detection method could obtain pathogenic bacteria information in 4 hr with high clinical sensitivity and specificity, which guided the faster antibiotic treatment in ICU and brought some clinical benefit in a real-world scenario.
    1. Epidemiology and Global Health

    Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa

    Oliver J Watson, Hannah C Slater ... Azra C Ghani
    The introduction of rapid diagnostic testing for Plasmodium falciparum infections can explain an increased emergence of diagnostic resistant pfhrp2-deleted parasites in sub-Saharan Africa.

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