David S Jacobs, Madeleine C Allen ... Bita Moghaddam
A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
GABA-A receptors on dopamine neuron axons not only depolarize the membrane but also limit action potential propagation, an effect potentiated by positive allosteric modulators of GABA-A receptors like diazepam (Valium).
The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.
Risk of punishment during reward seeking behavior is associated with a functional "disconnection" of the PFC-VTA circuit due to a transient loss of VTA-driven theta oscillation.
Mohit Dubey, Maria Pascual-Garcia ... Maarten HP Kole
Demyelination disrupts fast inhibition of pyramidal neurons, thereby changing neocortical rhythms and causing the emergence of brief epileptic-like discharges.
SOM+ GABAergic neuronal signaling and inhibitory transmission in the central lateral amygdala is regulated by TMEM16B, which is also involved in fear and anxiety-like behaviors.