40 results found
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy, Austin R Schinlever ... Anna R Cliffe
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Cell Biology
    2. Neuroscience

    The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

    Jana Dorfman Marcette, Jessica Jie Chen, Michael L Nonet
    The minus-ends of microtubules have been implicated as part of a damage sensor to initiate remodeling of nerve cells.
    1. Neuroscience

    Inhibiting poly(ADP-ribosylation) improves axon regeneration

    Alexandra B Byrne, Rebecca D McWhirter ... Marc Hammarlund
    In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.
    1. Developmental Biology
    2. Neuroscience

    Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub

    Melissa A Borgen, Andrew C Giles ... Brock Grill
    Genetic, developmental and pharmacological analysis in Caenorhabditis elegans demonstrate that ATAT-2 tubulin acetyltransferase activity regulates synapse maintenance by acting within the RPM-1 signaling network, but independent of the DLK-1 MAP3K.
    1. Cell Biology
    2. Neuroscience

    PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

    Claire E Richardson, Kerri A Spilker ... Kang Shen
    The protein PTRN-1 anchors microtubules in neuronal branches to promote proper neuron morphology and function in Caenorhabditis elegans.
    1. Neuroscience

    TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration

    Victoria L Czech, Lauren C O'Connor ... Alexandra B Byrne
    TIR-1 regulates both repair and destruction on either side of an injury axon.
    1. Neuroscience

    Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength

    Yunbo Li, Erin M Ritchie ... Yishi Jin
    The activity levels of two closely related MAPKKK are differentially regulated in Purkinje neuron survival.
    1. Neuroscience

    An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

    Yan Hao, Erin Frey ... Catherine Collins
    Axonal damage sensing kinase DLK is a direct target and mediator of the cAMP effector kinase PKA in a unified mechanism for stimulating axonal regeneration.
    1. Neuroscience

    Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

    Josette J Wlaschin, Jacob M Gluski ... Claire E Le Pichon
    The DLK response pathway in neurons initiates the cascade of events leading to neuropathic pain after injury.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li, Yao V Zhang ... Catherine A Collins
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.

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