2,943 results found
    1. Biochemistry and Chemical Biology

    Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3

    James E Collier, Byung-Gil Lee ... Kim A Nasmyth
    Rigorous biochemical and structural analyses reveal the precise topology of cohesin's association with DNA and suggest a mechanism for how DNA is transported inside the ring.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen, Deyang Xu ... Barbara Ann Halkier
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.
    1. Immunology and Inflammation

    Antigen receptor control of methionine metabolism in T cells

    Linda V Sinclair, Andrew JM Howden ... Doreen A Cantrell
    Antigen receptor control of methionine transport is critical to co-ordinate protein synthesis and the production of methyl donors for nucleotide and protein methylations which are required for T cell differentiation.
    1. Structural Biology and Molecular Biophysics

    Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations

    Maureen Leninger, Ampon Sae Her, Nathaniel J Traaseth
    Conservative mutations within a secondary active transport protein influenced the conformational equilibrium probed using NMR spectroscopy which correlated to the functional output in vivo.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

    Solveig G Schmidt, Andreas Nygaard ... Claus J Loland
    Potassium presumably binds to the Na1 site in LeuT, playing a role in inwardly rectifying the transport of substrates.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

    Zachary Lee Johnson, Jun-Ho Lee ... Seok-Yong Lee
    Studies of the substrate selectivity of concentrative nucleoside transporters provide proof of principle for structure-based improvement of drug delivery by these transporters.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Selection of chromosomal DNA libraries using a multiplex CRISPR system

    Owen W Ryan, Jeffrey M Skerker ... Jamie HD Cate
    An optimized CRISPR-Cas9 system enables multiplexed genome engineering for evolving biomolecules and pathways from chromosomally integrated DNA libraries.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

    Aaron T Bozzi, Christina M Zimanyi ... Rachelle Gaudet
    Nramp-family transporters adapt a common fold to a novel mechanism in which the spatial and temporal separation of like-charge transition metal and proton co-substrates circumvents the expected electrostatic repulsion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

    Joana A Santos, Stephan Rempel ... Dirk J Slotboom
    ECF-CbrT is a bacterial vitamin B12 transporter that is structurally different from the well-characterized transporter BtuCDF, yet has similar functional properties.
    1. Microbiology and Infectious Disease

    The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

    Hui Dong, Jiong Yang ... Shaojun Long
    Combined cutting-edge technologies discovered a pair of carboxylate transporters that appears evolutionarily different among novel transporters and that is essential for parasite physiology.

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