270 results found
    1. Evolutionary Biology

    Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

    Hironori Funabiki, Isabel E Wassing ... Thomas Carroll
    Coevolution analysis suggests that a DNA methylation-related role for the nucleosome remodeling ATPase HELLS and its activator CDCA7 was broadly inherited from the last eukaryotic common ancestor.
    1. Developmental Biology

    The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

    Ellen N Elliott, Karyn L Sheaffer, Klaus H Kaestner
    The maintenance methyltransferase Dnmt1 and the de novo methyltransferase Dnmt3b cooperate to maintain DNA methylation and genomic stability in the adult intestinal epithelium.
    1. Chromosomes and Gene Expression

    Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

    Heon Shin, Amy Leung ... Dustin E Schones
    Extracellular glucose promotes O-GlcNAcylation of DNMT1 and inhibition of DNMT1 function in the maintenance of genomic methylation.
    1. Neuroscience

    Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function

    Daniel Gerber, Monica Ghidinelli ... Ueli Suter
    In the peripheral nervous system, the large GTPase dynamin 2 is required for Schwann cell survival, developmental radial sorting of axons, myelination, and myelin maintenance.
    1. Cell Biology

    Dnmt3a is an epigenetic mediator of adipose insulin resistance

    Dongjoo You, Emma Nilsson ... Sona Kang
    Mouse and tissue culture studies reveal that adipose DNA methyltransferase 3a mediates insulin resistance, partially through repressing the expression of FGF21.
    1. Medicine

    GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

    Gaoran Ge, Qianping Guo ... Dechun Geng
    A new role is identified for GLI1 in modulating the inflammatory response of macrophages and the overaction of osteoclasts in collagen-induced arthritis by collaboratively regulating DNMT1 and DNMT3a.
    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia, Christopher Timmermann ... Robin L Carhart-Harris
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The long non-coding RNA Dali is an epigenetic regulator of neural differentiation

    Vladislava Chalei, Stephen N Sansom ... Chris P Ponting
    Dali regulates transcription of the Pou3f3 locus locally and binds and regulates active promoters in trans by modulating DNA methylation status.
    1. Genetics and Genomics

    Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

    Thomas A Sasani, Brent S Pedersen ... Aaron R Quinlan
    Rates of germline mutation accumulation are highly variable across families of similar genetic ancestry, and post-zygotic mosaicism is a substantial source of de novo mutations.

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