12,376 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

    Eric T Domyan, Zev Kronenberg ... Michael D Shapiro
    Feathered feet of pigeons and chickens result from a partial molecular and morphological transformation of legs to a wing-like identity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Reconstitution of bacterial autotransporter assembly using purified components

    Giselle Roman-Hernandez, Janine H Peterson, Harris D Bernstein
    A complex that catalyzes the membrane integration of β barrel proteins and a molecular chaperone promote the complete assembly of a bacterial virulence factor in vitro.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

    Martial Marbouty, Axel Cournac ... Romain Koszul
    A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

    Patrick T Dolan, Shuhei Taguwa ... Judith Frydman
    Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.
    1. Neuroscience

    Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

    Yunzhe Liu, Raymond J Dolan ... Timothy E Behrens
    Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
    1. Microbiology and Infectious Disease

    The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell

    Jennifer E Dumaine, Adam Sateriale ... Boris Striepen
    Following initial invasion events, intracellular life stages of C. parvum rely upon an N-terminal host-targeting motif and proteolytic processing at a specific leucine residue to deliver proteins into the infected enterocyte.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

    Roman Sloutsky, Kristen M Naegle
    Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

    Adrian L Sanborn, Benjamin T Yeh ... Roger D Kornberg
    Transcriptional activation domains achieve rapid, dynamic, specific interaction with Mediator through binding of an unstructured peptide to multiple hydrophobic surfaces without particular amino acid side chain interactions.
    1. Neuroscience

    A map of abstract relational knowledge in the human hippocampal–entorhinal cortex

    Mona M Garvert, Raymond J Dolan, Timothy EJ Behrens
    Map-like organisations of relational knowledge can be extracted from the hippocampal-entorhinal system in situations where relationships are non-spatial rather than spatial, discrete rather than continuous, and unavailable to conscious awareness.
    1. Neuroscience

    Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

    Carlos G Moreira, Christian R Baumann ... Daniela Noain
    Delivery of auditory triggers as unique slow waves-targeting approach yields efficient, stable, and precise modulation of slow-wave activity in rats.

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