Kee Wui Huang, Nicole E Ochandarena ... Bernardo L Sabatini
The dorsal raphe nucleus contains transcriptionally diverse cell classes that include subtypes of serotonergic neurons with distinct molecular and anatomical signatures.
Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.
The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.
Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
The most comprehensive neuroanatomical atlas on the expression of three glycoprotein hormone receptors, namely, TSHRs, LHCGRs, and FSHRs, was mapped using RNAscope, a technology that allows the detection of mRNA at single-transcript level.
Neurexins are presynaptic adhesion molecules in the serotonin system which regulate neuron survival and serotonin neuromodulation through active zone formation and serotonin release.
Patrícia A Correia, Eran Lottem ... Zachary F Mainen
Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
Emerson F Harkin, Michael B Lynn ... Jean-Claude Béïque
A new type of biologically constrained spiking neural network model applied to the dorsal raphe nucleus shows that the output of the serotonin system reflects not just its raw input, but mainly how quickly its input changes over time.