1,057 results found
    1. Chromosomes and Gene Expression

    DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

    Faith C Fowler, Bo-Ruei Chen ... Jessica K Tyler
    Molecular analyses and unbiased CRISPR screens reveal that extensive end resection occurs in quiescent cells after inducing DNA double strand breaks, in a manner dependent on DNA-PK.
    1. Chromosomes and Gene Expression

    Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

    Nicola Manfrini, Michela Clerici ... Maria Pia Longhese
    The conversion of the ends of a double-strand break from double-stranded to single-stranded DNA, which is necessary to initiate homologous recombination, is responsible for loss of transcription and RNA polymerase occupancy around the double-strand break in Saccharomyces cerevisiae.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

    Bryan A Leland, Angela C Chen ... Megan C King
    A single-cell assay reveals that the genetic rewiring that underlies PARP inhibitor resistance drives altered DNA double-strand break end resection pathway choice.
    Short Report Updated
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.

    Saravanapriah Nadarajan, Talley J Lambert ... Monica P Colaiácovo
    PLK-1/2-mediated SYP-4 phosphorylation is dependent on crossover precursor formation, triggering a switch in the dynamic state of the synaptonemal complex that reduces the formation of further double-strand breaks at late meiotic prophase.
    1. Cell Biology
    2. Genetics and Genomics

    Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

    Heyun Guo, Ericca L Stamper ... Peter M Carlton
    Opposing activities of ATR kinase and PP4 phosphatase balance phosphorylation of the protein DSB-1 to produce sufficient but not excessive amount of DNA double-strand breaks during meiotic prophase in Caenorhabditis elegans.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila

    Cathleen M Lake, Rachel J Nielsen ... R Scott Hawley
    The Zip3-like protein Vilya links the initiation of meiotic recombination with crossover formation.
    1. Chromosomes and Gene Expression

    DNA Damage: Proteins pinpoint double strand breaks

    Michael M Cox
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    1. Cell Biology

    SIRT6 is a DNA double-strand break sensor

    Lior Onn, Miguel Portillo ... Debra Toiber
    Hundreds of proteins are involved in the DNA damage response but only three sensors for DSB were known but now SIRT6 is identified as a fourth DSB sensor.
    1. Developmental Biology
    2. Genetics and Genomics

    Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice

    Mohamed Mahgoub, Jacob Paiano ... Todd S Macfarlan
    The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.
    1. Cell Biology

    Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

    Songli Zhu, Mohammadjavad Paydar ... Aimin Peng
    Kinesin Kif2C is recruited to DNA damage sites, modulates the mobility and dynamics of DNA damage foci, and promotes DNA double strand break repair.

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