2,555 results found
    1. Genetics and Genomics
    2. Neuroscience

    Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules

    Savannah G Brovero, Julia C Fortier ... Michelle N Arbeitman
    Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

    Daniela Justa-Schuch, Maria Silva-Garcia ... Ruth Geiss-Friedlander
    Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.
    1. Cell Biology
    2. Developmental Biology

    Dpp from the anterior stripe of cells is crucial for the growth of the Drosophila wing disc

    Shinya Matsuda, Markus Affolter
    A recent report proposing that the dpp stripe (the main source of the protein dpp) is dispensable for Drosophila wing disc growth missed the critical role on growth due to imprecise spatial removal of dpp.
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    1. Cell Biology
    2. Developmental Biology

    Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

    Niklas Simon, Abu Safyan ... Shinya Matsuda
    The heparan sulfate chains of the glypican Dally stabilizes morphogen Dpp on the cell surface by antagonizing receptor-mediated Dpp internalization largely independent of direct interaction with Dpp.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

    Nidhi Sharma Dey, Parvathy Ramesh ... Lolitika Mandal
    Identification of Hematopoietic stem cells (HSCs) in the genetically amenable organism Drosophila melanogaster paves the path to address HSC biology, both in normal and pathophysiological conditions.
    1. Neuroscience

    Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

    Sahab Arinrad, Constanze Depp ... Klaus-Armin Nave
    Loss of myelin integrity in the mouse forebrain perturbs executive functions, assessed by tests requiring normal motor performance.
    1. Cell Biology
    2. Developmental Biology

    Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

    Pablo Sanchez Bosch, Ruta Ziukaite ... Jean-Paul Vincent
    Striped expression of Dpp in Drosophila wing precursors leads to graded signalling activity that positions wing veins and, in parallel, promotes growth in a gradient-independent manner by supplying signalling activity above a threshold.
    1. Neuroscience

    APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

    Ming Chen, Jinzhao Wang ... Li Yang
    APP interacts with KCC2 to limit the latter from tyrosine-phosphorylation and ubiquitination and thus subsequent degradation, revealing a novel molecular pathway in which APP regulates GABAergic signaling and thus inhibition in the hippocampus.
    1. Developmental Biology
    2. Neuroscience

    Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10

    Lalanti Venkatasubramanian, Zhenhao Guo ... Richard S Mann
    Ig domain family members DIP-alpha and Dpr10 are required in a subset of Drosophila leg motor neurons and muscles, respectively, to establish their fine terminal branching pattern and synapses.
    1. Developmental Biology

    Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing

    Lara Barrio, Marco Milán
    Dpp emanating from the anterior-posterior compartment boundary is continuously required to promote proliferative growth of the whole fly wing appendage.

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