1,961 results found
    1. Neuroscience

    Fast and accurate annotation of acoustic signals with deep neural networks

    Elsa Steinfath, Adrian Palacios-Muñoz ... Jan Clemens
    DAS is a universal tool for segmenting and identifying acoustic signals in single and multi channel recordings robustly, reliably, and at low latency.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer, Christian Scheeder ... Michael Boutros
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sweepstakes reproductive success via pervasive and recurrent selective sweeps

    Einar Árnason, Jere Koskela ... Bjarki Eldon
    Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

    Caleb N Fischer, Eric P Trautman ... Nichole A Broderick
    Interactions between fungal and bacterial microbiome members alter Drosophila melanogaster's chemical environment, affecting host behavior and survival.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang, Michael Ly ... Olivia S Rissland
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.
    1. Cell Biology
    2. Neuroscience

    Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

    Friederike E Kohrs, Ilsa-Maria Daumann ... P Robin Hiesinger
    The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.
    1. Cell Biology

    Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

    Kathryn E Kistler, Tatjana Trcek ... Ruth Lehmann
    The scaffolding protein Oskar organizes two types of germ granules by phase transition within the same cell but with distinct morphologies, composition and biological functions.
    1. Evolutionary Biology

    Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox

    Vince Buffalo
    Quantifying the relationship between census sizes and genetic diversity estimates provides insights into whether natural selection can explain the narrow range of diversity between species.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos

    Stephen W Eichhorn, Alexander O Subtelny ... David P Bartel
    Profiling of mRNA poly(A)-tail lengths and translational efficiencies provides new insights into posttranscriptional gene regulation in early Drosophila development.
    1. Cell Biology
    2. Genetics and Genomics

    A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

    Dana M Talsness, Katie G Owings ... Clement Y Chow
    An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.

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