4,077 results found
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

    Luis Miguel Díaz-Santín, Natasha Lukoyanova ... Alan CM Cheung
    An atomic model of the 3744-residue Tra1 protein reveals multiple transcription activator binding sites, its integration within the SAGA chromatin coactivator complex, and a striking similarity to DNA-repair factor DNA-PKcs.
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

    Antonion Korcari, Anne EC Nichols ... Alayna E Loiselle
    Age-related tendon degeneration is initiated by loss of tenocytes associated with synthesis of high-turnover rate proteoglycans and glycoproteins.
    1. Physics of Living Systems

    Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility

    Elizabeth Eck, Jonathan Liu ... Hernan G Garcia
    Confronting different models of chromatin accessibility with temporally resolved transcription profiles favors a scenario where transcription factors actively, rather than passively, drive chromatin from the inaccessible to the accessible state.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling

    Deepti Trivedi, Vinitha CM ... Padinjat Raghu
    A genome editing resource for discovering, in Drosophila, the organization of cellular structure and function by phosphoinositide signaling.
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim, Lea Adolf ... Simon Heilbronner
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Immunology and Inflammation
    2. Neuroscience

    MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Oligodendroglia express major histocompatibility complex (MHC) pathways in response to inflammation and MHC reporter mice allow for the investigation of MHC molecule expressing cells in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    γ-Protocadherin structural diversity and functional implications

    Kerry Marie Goodman, Rotem Rubinstein ... Lawrence Shapiro
    Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis data identify the putative cis interface.
    1. Structural Biology and Molecular Biophysics

    Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

    Naotaka Tsutsumi, Somnath Mukherjee ... K Christopher Garcia
    Cryo-EM structure of monomeric human Frizzled5 was determined with a universal fiducial antibody at 3.7 Å overall resolution, which supports a simple Fzd/LRP6 heterodimerization mechanism of canonical Wnt/β-catenin signaling.
    1. Cell Biology
    2. Developmental Biology

    A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea

    Arzu Öztürk-Çolak, Bernard Moussian ... Jordi Casanova
    Cell-cell junctions and the actin cytoskeleton are key players in the organisation and patterning of the extracellular matrix (ECM) on the apical side of tracheal cells.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4

    John M Nicoludis, Bennett E Vogt ... Rachelle Gaudet
    Clustered and non-clustered protocadherins form antiparallel homodimers in which distinct regions of the extended interface demonstrate a division of labor between driving affinity and determining specificity.
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