Single molecule DNA-binding trajectories and deterministic modeling analyses demonstrate a functional role for high energy partly folded states in Transcription Activator-Like Effectors that could improve future TALEN design.
Vanessa Lage-Rupprecht, Li Zhou ... Veronica Egger
The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.
Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
The representations of information concerning the number, size, density and surface of sets of objects in a visual image are separable along the occipito-parietal cortex and independently modulated by attention.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
A complex colour polymorphism which links colour with behavioural and life-history traits is associated with a single gene duplication in male wood tiger moths.
Yangfan Peng, Franz Xaver Mittermaier ... Jörg Rolf Paul Geiger
Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
Mice that lack the autism susceptibility gene Semaphorin 5A show excess excitatory synapse formation in dentate granule neurons and also altered social behavior, adding to evidence that a surplus of synapses contributes to the behavioral changes observed in autism spectrum disorders.
Yevgeniya A Mironova, Guy M Lenk ... Roman J Giger
The signaling lipid PI(3,5)P2 supports the formation of the myelin sheath, by regulating trafficking of myelin building blocks within oligodendrocytes and communication between oligodendrocytes and neuronal axons.
