17,476 results found
    1. Ecology
    2. Evolutionary Biology

    Dynamics of venom composition across a complex life cycle

    Yaara Y Columbus-Shenkar, Maria Y Sachkova ... Yehu Moran
    Different developmental stages of a venomous animal (e.g. Nematostella vectensis) with a complex life cycle produce vastly different venoms that can serve in different antagonistic interactions with other species.
    1. Epidemiology and Global Health

    Future life expectancy in Europe taking into account the impact of smoking, obesity, and alcohol

    Fanny Janssen, Anastasios Bardoutsos ... Joop De Beer
    Accounting for the impact of smoking, obesity, and alcohol on past mortality trends, we project, compared to common practice, longer individual lifespans and more elderly in society for the future.
    1. Genetics and Genomics

    Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations

    M Elise Lauterbur, Maria Izabel A Cavassim ... Ilan Gronau
    Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of clonal multicellular life cycles

    Vanessa Ress, Arne Traulsen, Yuriy Pichugin
    The evolution of clonal multicellular life cycles, whose growth is constrained by competition, may lead to coexistence or multistability between several life cycles while evolutionarily stable strategies can be inferred from the analysis of a model with unconstrained growth.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai, Catherine Julien ... Mathieu Ferron
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Developmental Biology
    2. Neuroscience

    Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

    Jennifer A Honeycutt, Camila Demaestri ... Heather C Brenhouse
    Early life adversity led to hyper-innervation from the basolateral amygdala to the prefrontal cortex earlier in females than males and disrupted maturation of functional connectivity, which predicted anxiety-like outcomes.
    1. Immunology and Inflammation

    Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

    Brogan Yarzabek, Anita J Zaitouna ... Malini Raghavan
    Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
    1. Neuroscience

    Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment

    Aniket Ghosh, Elise LV Malavasi ... Peter J Brophy
    Neuronal neurofascin takes a surprisingly circuitous route in the neuronal plasma membrane to the axon initial segment where it stabilises ion channel complexes responsible for initiating action potentials.
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    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba, Minoas Evangelinos ... Bruno André
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Neuroscience

    Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development

    Gabriela Manzano Nieves, Marilyn Bravo ... Kevin G Bath
    Early life adversity (ELA) accelerated PV+ interneuron development in BLA and delayed the ability of pre-adolescent mice to express, but not form, an auditory conditioned fear memory in childhood.

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