769 results found
    1. Developmental Biology

    Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin

    Andrew J Aman, Lauren M Saunders ... David M Parichy
    Single-cell transcriptomics enables functional dissection of signaling interactions that drive morphogenesis of complex organ systems.
    1. Developmental Biology
    2. Evolutionary Biology

    The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

    Suparna Ray, Miriam I Rosenberg ... François Payre
    mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang, Jean-François Rupprecht, Timothy E Saunders
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.
    1. Computational and Systems Biology
    2. Developmental Biology

    A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages

    Inna Averbukh, Sen-Lin Lai ... Naama Barkai
    The demand for robust performance distinguishes the mechanism which progresses the biological timer acting within neural progenitors to determine neuronal fates in the Drosophila embryo.
    1. Computational and Systems Biology
    2. Developmental Biology

    Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

    Idse Heemskerk, Kari Burt ... Aryeh Warmflash
    Live cell imaging demonstrates that the dynamics of ligand presentation influence signaling through two closely related morphogen signaling pathways in dramatically different ways.
    1. Developmental Biology
    2. Evolutionary Biology

    Dual mode of embryonic development is highlighted by expression and function of Nasonia pair-rule genes

    Miriam I Rosenberg, Ava E Brent ... Claude Desplan
    Pair-rule genes in the wasp Nasonia function as in Drosophila in patterning anterior segments, and similar to ancestral insects in patterning posterior segments, illustrating a mixed-mode transition state between short and long germ embryogenesis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

    Isabella V Soluri, Lauren M Zumerling ... Shelby A Blythe
    Mechanisms for shaping the chromatin accessibility landscape operate during development to regulate how embryonic patterning information is interpreted at the level of gene regulatory networks.
    1. Developmental Biology

    Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

    Brent W Bisgrove, Yi-Chu Su, H Joseph Yost
    Maternal Gdf3 and Nodal are interdependent obligatory cofactors in the fundamental patterning of the vertebrate embryonic axis of zebrafish.
    1. Developmental Biology

    ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny

    Joseph M Chambers, Shahram Jevin Poureetezadi ... Rebecca A Wingert
    The transcriptional coactivator ppargc1a regulates the renal progenitor patterning to delineate boundary formation of differentiated segment populations during nephrogenesis.
    1. Developmental Biology

    Nodal patterning without Lefty inhibitory feedback is functional but fragile

    Katherine W Rogers, Nathan D Lord ... Alexander F Schier
    Lefty-mediated feedback inhibition of Nodal signaling mitigates signaling perturbations, but is dispensable for development.

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