2,841 results found
    1. Neuroscience

    A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans

    Laura D Lewis, Giovanni Piantoni ... Patrick L Purdon
    Intracranial recordings of human brain activity during awakening from general anesthesia exhibit a brief brain state not seen during loss of consciousness, in which stimuli elicit large electrophysiological responses that resemble those seen in sleep.
    1. Stem Cells and Regenerative Medicine

    Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

    Yaeko Nakajima-Takagi, Motohiko Oshima ... Atsushi Iwama
    Polycomb repressive complex 1.1 restricts precocious myeloid differentiation of hematopoietic stem/progenitor cells and expansion of myeloid progenitors, thereby serving as a gatekeeper of emergency myelopoiesis and myeloid transformation.
    1. Microbiology and Infectious Disease

    T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

    Matthew D Lauver, Ge Jin ... Aron E Lukacher
    Loss of T cell control during persistent polyomavirus infection, in the setting of a limited antiviral antibody response, facilitates emergence of antibody-escape viruses carrying the potential for neurovirulence.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

    Bronner P Gonçalves, Matthew Hall ... ISARIC Clinical Characterisation Group
    Combined analyses of publicly available population-level variant data and detailed individual-level clinical data can be used to quantify the clinical impact of new SARS-CoV-2 variants in different settings.
    1. Computational and Systems Biology
    2. Neuroscience

    Interrogating theoretical models of neural computation with emergent property inference

    Sean R Bittner, Agostina Palmigiano ... John Cunningham
    Emergent property inference, a novel machine learning methodology, learns distributions of neural circuit model parameters that produce computational properties and provides novel scientific insight through the quantification of the rich parametric structure it captures.
    1. Neuroscience

    Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

    Kate Nussenbaum, Catherine A Hartley
    The use of prior experience to adaptively prioritize information in memory increases from childhood to adulthood and engages corticostriatal circuitry.
    1. Neuroscience

    A transient postnatal quiescent period precedes emergence of mature cortical dynamics

    Soledad Domínguez, Liang Ma ... Jennifer N Gelinas
    Maturation of cortical network dynamics is characterized by a nadir that signals the shift from local, loosely correlated, prominently sensory-driven patterns to internally organized, spatially distributed, and temporally precise activity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

    Katina D Hulme, Anjana C Karawita ... Kirsty R Short
    Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

    Sean M Braet, Theresa SC Buckley ... Ganesh S Anand
    Structural mass spectrometry reveals conformational changes in emerging SARS-CoV-2 spike protein variants that correlate with increased viral fitness.
    1. Ecology

    Habitat and social factors shape individual decisions and emergent group structure during baboon collective movement

    Ariana Strandburg-Peshkin, Damien R Farine ... Iain D Couzin
    For baboons on the move, habitat features across multiple spatial scales combine with social interactions to impact the movements of individuals, ultimately shaping the structure of the whole group.

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