In the bacterial small multidrug transporter EmrE, sidechain rearrangements in the binding site accommodate structurally diverse substrates without major rearrangements of the protein backbone.

While flooding events may drive spillover transmission of Leptospira spp. through dispersal of the bacteria at low elevations, at higher elevations environmental risk is more localised and directly driven by the distribution of local rat reservoir populations.

Building on previous work (Tang et al., 2015), novel ESCRT-III subunit Snf7 auto-activation mutants are used to reveal two parallel ubiquitin-dependent pathways during multivesicular endosome biogenesis.

The lysosome membrane is a new functional location for the ESCRTs in yeast.

A number of microbial eukaryotes have adapted to low oxygen conditions by acquiring a gene that allows their mitochondrial electron transport chain to continue to function when oxygen is scarce.

Thousands of small Open Reading Frames are translated, and form two distinct classes based on their translational efficiency and bioinformatic indicators.

Presynaptic GABAB receptors are highly expressed and strongly suppress synaptic transmission at the input and output of hippocampal somatostatin interneurons.

Ubiquitin ligase adaptors target the selective clearance of misfolded plasma membrane proteins.

Integrative structural biology reveals a novel complex comprising the TATA-box-binding protein, TBP, and two subunits, TAF11 and TAF13, of General Transcription Factor TFIID, suggesting a new regulatory state in TFIID function in RNA polymerase II transcription initiation.

Subterranean isopods endemic to regions with large igneous rock formations have a higher mutation rate and display an excess of mutations that are typical of an oxidative stress.