176 results found
    1. Structural Biology and Molecular Biophysics

    Encounter complexes and dimensionality reduction in protein–protein association

    Dima Kozakov, Keyong Li ... Sandor Vajda
    Analysis of protein–protein encounter complexes shows that proteins associate along preferred pathways, similar to the sliding of a protein along DNA.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

    Xiakun Chu, Zucai Suo, Jin Wang
    The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.
    1. Structural Biology and Molecular Biophysics

    High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

    Zhijie Chen, Ronen Gabizon ... Carlos Bustamante
    Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.
    1. Ecology
    2. Evolutionary Biology

    Host-parasite coevolution promotes innovation through deformations in fitness landscapes

    Animesh Gupta, Luis Zaman ... Justin R Meyer
    An interdisciplinary approach combining high throughput genotype-to-phenotype mapping, population genetic simulations, and experimental evolution provides an answer to the question of how populations evolve new functions by providing tests of the role antagonistic coevolution plays in pressuring populations to innovate.
    1. Immunology and Inflammation

    Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

    Isaac J Jensen, Xiang Li ... Vladimir P Badovinac
    Sepsis leads to lasting changes in the composition of the pre-existing memory CD8 T cell compartment leading to altered localization, changes in their transcriptional landscape and chromatin accessibility, differential function, and reduced capacity to control infection.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

    Felix Horns, Christopher Vollmers ... Stephen R Quake
    A comprehensive map of patterns of class switching reveals how antibodies of every class are created in humans.
    1. Ecology

    Linking spatial patterns of terrestrial herbivore community structure to trophic interactions

    Jakub Witold Bubnicki, Marcin Churski ... Dries PJ Kuijper
    The spatial interactions between humans, large carnivores and herbivores cascade down in a complex but predictable way to lower trophic levels affecting regeneration of tree species in a temperate forest.
    1. Ecology
    2. Evolutionary Biology

    Novel pathogen introduction triggers rapid evolution in animal social movement strategies

    Pratik Rajan Gupte, Gregory F Albery ... Franz J Weissing
    The introduction of infectious pathogens to a simulated animal population leads to rapid evolutionary transitions in how individuals move in a social context, with distinct movement morphs evolved that make trade-offs between sociality and infection risk.
    1. Neuroscience
    2. Physics of Living Systems

    Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters

    Mahmut Demir, Nirag Kadakia ... Thierry Emonet
    Visualized odor encounters show that Drosophila navigate spatiotemporally complex odor plumes using random walks biased by the timing of brief and unpredictable odor encounters.
    1. Ecology

    Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

    Xueyou Li, William V. Bleisch ... Xuelong Jiang

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