751 results found
    1. Developmental Biology

    Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

    Shreyasi Mukherjee, Praneet Chaturvedi ... Aaron M Zorn
    Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
    1. Cell Biology
    2. Developmental Biology

    PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix

    S Nahuel Villegas, Michaela Rothová ... Joshua M Brickman
    A signalling cascade involving PI3K/Akt1 remodels the extra-cellular matrix to achieve atypical cellular responses and control cell fate specification within the embryonic endoderm.
    1. Developmental Biology

    Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids

    Ali Hashmi, Sham Tlili ... Pierre-François Lenne
    A cellular and biophysical study on embryonic stem cell aggregates reveals that the endoderm can form by a three-step mechanism involving a Wnt/beta-catenin-mediated epiblast fragmentation, tissue flow and cell segregation.
    1. Cell Biology
    2. Genetics and Genomics

    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation

    Alexandro Landshammer, Adriano Bolondi ... Alexander Meissner
    Discovery of a novel long non-coding RNA overlapping the distal SOX17 enhancer (eSOX17) that plays an essential role in human endoderm development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

    Marta Perera, Silas Boye Nissen ... Joshua M Brickman
    The simultaneous expansion of G1 and acceleration of the cell cycle, while ensuring synchronous inheritance of these properties, progressively induces cell identity in differentiation.
    1. Cell Biology
    2. Developmental Biology

    Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula

    Jason WH Wen, Rudolf Winklbauer
    The cellular behaviours that underlie the internalization of the multilayered endoderm anlage in Xenopus laevis link the ancestral mode of vertebrate gastrulation to common, epithelial-based mechanisms of gastrulation in non-vertebrate animals.
    1. Cell Biology
    2. Developmental Biology

    An in vitro stem cell model of human epiblast and yolk sac interaction

    Kirsty ML Mackinlay, Bailey AT Weatherbee ... Magdalena Zernicka-Goetz
    Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.
    1. Genetics and Genomics
    2. Plant Biology

    The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons

    Rita A Batista, Jordi Moreno-Romero ... Claudia Köhler
    Jumping of transposable elements provides DNA-binding sites for the MADS-box transcription factor PHERES1, allowing the regulation of imprinted genes and other key endosperm development genes.
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    1. Chromosomes and Gene Expression

    Combinations of maternal-specific repressive epigenetic marks in the endosperm control seed dormancy

    Hikaru Sato, Juan Santos-González, Claudia Köhler
    Analyses of cell type-specific data show that the maternal alleles of genes related to establishing and breaking seed dormancy are suppressed by different combinations of epigenetic marks in the endosperm of Arabidopsis.
    1. Plant Biology

    Auxin production in the endosperm drives seed coat development in Arabidopsis

    Duarte D Figueiredo, Rita A Batista ... Claudia Köhler
    Auxin is produced in the endosperm after fertilization and drives the development of the seed coat in Arabidopsis.

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