1,203 results found
    1. Cancer Biology

    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

    Sumiko Takao, Lauren Forbes ... Alex Kentsis
    Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.
    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan, Yun-Yu Tseng ... Oliver Florey
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    1. Chromosomes and Gene Expression

    Genomic DNA transposition induced by human PGBD5

    Anton G Henssen, Elizabeth Henaff ... Alex Kentsis
    The human PGBD5 gene encodes an active DNA transposase.
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens, Thaleia Papadopoulou ... Pablo Navarro
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Cell Biology
    2. Computational and Systems Biology

    Regulation of mRNA translation during mitosis

    Marvin E Tanenbaum, Noam Stern-Ginossar ... Ronald D Vale
    Ribosomal profiling reveals that translational repression is an important mechanism for cell cycle control and can complement protein degradation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    Tao Zhang, Liyang Wan ... Hongbin Lu
    Single-cell RNA sequencing to delineate the comprehensive postnatal RC enthesis growth from as early as postnatal day 1 to postnatal day 56.
    1. Cell Biology

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    Rebecca S Mathew, Antonis Tatarakis ... Danesh Moazed
    A fear conditioning-induced miRNA acts in a negative feedback loop that targets vesicle exocytosis and neurotransmitter receptor trafficking, and inhibits memory formation.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou, Kuhulika Bhalla ... Bruce Stillman
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Evolutionary Biology
    2. Medicine

    Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

    Antonis Rokas, Sam Mesiano ... Louis Muglia
    This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
    1. Cell Biology

    G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion

    Vladimir Purvanov, Manuel Holst ... Robert Grosse
    siRNA knockdown experiments reveal in detail the signaling pathway that controls cytoskeletal function during cell-in-cell invasion.

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