The prokaryotic actin homologue MreB forms antiparallel double filaments in vitro and in vivo, an architecture that is unprecedented among the actin family of proteins.

At most physiological concentrations, the short-chain fatty acids propionate and butyrate affect histone acetylation by modifying and activating the acetyltransferase p300/CBP, rather than by inhibiting histone deacetylases.

Molecular analyses and unbiased CRISPR screens reveal that extensive end resection occurs in quiescent cells after inducing DNA double strand breaks, in a manner dependent on DNA-PK.

During centrosome maturation, pericentrin is delivered to the centrosome co-translationally by a microtubule- and dynein-dependent process, as pericentrin mRNA is undergoing active translation near the centrosome.

A molecular interpretation is provided for why some inhibitory immunoreceptors prefer to recruit SHP1 but others prefer SHP2.

MMP14 activity-mediated cleavage of the ectodomain of PTH1R modulates PTH signaling in the chondrocyte-derived osteoblast lineage, regulating osteogenesis and thereby bone metabolism, with therapeutic significance for bone-wasting diseases.

Alpha EEG oscillations emerge at 4 months of age during sevoflurane general anesthesia, and unlike in adults, have a widespread spatial distribution that likely reflects differences in brain development.

Integrated stress response-induced expression of ATF4 and its transactivation of SOX9 causes aberrant chondrocyte differentiation and skeletal defects which can be alleviated by modulating initiation-factor eIF2α phosphorylation translation control.

MBLAC1 is an endoribonuclease specific for replication dependent histone pre-mRNA processing during S-phase and may represent a new type of cancer target.

MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.