1,147 results found
    1. Cell Biology

    Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function

    Logesvaran Krshnan, Wingyan Skyla Siu ... Pedro Carvalho
    Biochemical and genetic approaches revealed a posttranslational mechanism controlling the abundance of SUN2, a critical nuclear envelope protein.
    1. Neuroscience

    Nuclear envelope protein MAN1 regulates clock through BMAL1

    Shu-Ting Lin, Luoying Zhang ... Ying-Hui Fu
    A protein within the nuclear membrane, MAN1, controls the expression of the circadian clock gene, BMAL1, in an example of cross-talk between two major gene regulatory pathways.
    1. Cell Biology

    An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

    David J Thaller, Matteo Allegretti ... C Patrick Lusk
    ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
    1. Chromosomes and Gene Expression

    Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis

    Hanumanthu BD Prasada Rao, Takeshi Sato ... Akira Shinohara
    Cytological analyses combined with in vitro liposome reconstitution reveal that yeast SUN domain protein, Mps3, shows meiosis-specific phosphorylation in the luminal region of the nuclear envelope during meiosis for chromosome motion and nuclear envelope remodelling.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors

    Daniel Blanco-Melo, Robert J Gifford, Paul D Bieniasz
    The reconstitution of a functional envelope protein from an extinct hominid retrovirus reveals its receptor and an ancient host defense that may have led to the extinction of the virus.
    1. Microbiology and Infectious Disease

    MARCH8 inhibits viral infection by two different mechanisms

    Yanzhao Zhang, Takuya Tada ... Kenzo Tokunaga
    The host transmembrane protein MARCH8, previously known as an expression regulator of host proteins, is a powerful antiviral host factor with a potentially broad antiviral spectrum through two different mechanisms.
    1. Structural Biology and Molecular Biophysics

    Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

    Andrew J Borst, Connor E Weidle ... David Veesler
    An integrative structural and biophysical workflow indicates engagement of VRC01 germline antibodies can occur with a gp120 426c core construct containing all wild-type N-linked glycosylation sites, including the Asn276 glycan.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Deep learning-driven insights into super protein complexes for outer membrane protein biogenesis in bacteria

    Mu Gao, Davi Nakajima An, Jeffrey Skolnick
    An example of a deep learning-based strategy to discover novel protein-protein interactions and predict their complex structures at high accuracy.
    1. Cell Biology
    2. Developmental Biology

    Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope

    Robert Becker, Silvia Vergarajauregui ... Felix B Engel
    Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.
    1. Cell Biology
    2. Developmental Biology

    AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

    Silvia Vergarajauregui, Robert Becker ... Felix B Engel
    AKAP6 is a site-specific adaptor required and sufficient to anchor centrosomal proteins and golgi to the nuclear envelope and establishes a non-centrosomal microtubule organization center (ncMTOC).

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