1,240 results found
    1. Neuroscience

    cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

    Xin-Tai Wang, Lin Zhou ... Ying Shen
    Mouse models with specific presynaptic knockout demonstrate that Rim1α is subjected to threonine phosphorylation by a novel EPAC-PKCε module, which is essential to presynaptic transmitter release, required for the induction of presynaptic LTP, and critical for motor learning.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The elemental mechanism of transcriptional pausing

    Jason Saba, Xien Yu Chua ... Robert Landick
    Biochemical analyses of transcription complexes, including kinetic studies and probes of translocational and conformational states, establish the elemental mechanism of pausing, which underlies regulation of gene expression in all organisms.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

    Kunal Sharma, Neeraj Dhar ... John D McKinney
    Live-cell imaging captures the heterogenity of bacterial growth within intracellular bacterial communities and demonstrates that the constituent bacteria are protected from clearance by antibiotics delivered with a physiologically relevant pharmacodynamic profile.
    1. Chromosomes and Gene Expression

    Rapid epigenetic adaptation to uncontrolled heterochromatin spreading

    Jiyong Wang, Bharat D Reddy, Songtao Jia
    Redundant pathways prevent heterochromatin spreading and ectopic heterochromatin assembly; and plasticity of heterochromatin assembly allows cells to adapt to heterochromatin stress.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin, Naama Katsowich ... Nathalie Q Balaban
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Microbiology and Infectious Disease

    Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with UTIs

    Anna Sintsova, Arwen E Frick-Cheng ... Harry Mobley
    Conserved transcriptomic profile of uropathogenic E. coli in patients identifies an infection-specific metabolic state.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase

    Gulzhan Raiymbek, Sojin An ... Kaushik Ragunathan
    A putative histone demethylase in fission yeast has non-enzymatic properties that regulates heterochromatin assembly and epigenetic inheritance.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

    Jingxiang Li, Shupan Guo ... Haiyan Ren
    Transient interactions between NleE and PMSD10 suppress PSMD10 interaction with ATG7 to attenuate host autophagosome formation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding, Henry Louis Schreiber IV ... Edward H Egelman
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    High fat diet induces microbiota-dependent silencing of enteroendocrine cells

    Lihua Ye, Olaf Mueller ... John F Rawls
    Enteroendocrine cells sense nutrients in the gut and regulate digestive physiology but are rendered insensitive following fat ingestion due to alteration of gut microbiota.

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