713 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

    Alex N Nguyen Ba, Katherine R Lawrence ... Michael M Desai
    A bulk barcoded quantitative trait locus approach increases the power and resolution of genotype-phenotype mapping in yeast, revealing that the genetic architecture of 18 complex traits is highly polygenic, and is characterized by widespread epistatic interactions and pleiotropic effects.
    1. Evolutionary Biology

    Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

    Dave W Anderson, Alesia N McKeown, Joseph W Thornton
    Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Global epistasis emerges from a generic model of a complex trait

    Gautam Reddy, Michael M Desai
    Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Epistasis and entrenchment of drug resistance in HIV-1 subtype B

    Avik Biswas, Allan Haldane ... Ronald M Levy
    Drug resistance in HIV is the result of mutations, which affect fitness depending on epistatic interactions with the entire sequence background that varies within and between patient populations.
    1. Genetics and Genomics

    On the mechanistic nature of epistasis in a canonical cis-regulatory element

    Mato Lagator, Tiago Paixão ... Călin C Guet
    Thermodynamic framework accurately predicts the sign of epistasis and its environment dependence for a canonical cis-regulatory element.
    1. Plant Biology

    Combining growth-promoting genes leads to positive epistasis in Arabidopsis thaliana

    Hannes Vanhaeren, Nathalie Gonzalez ... Dirk Inzé
    Pairwise combinations of growth-promoting genes regulating distinct cellular mechanisms lead to synergistic effects on leaf growth, and hence greatly increased leaf size.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic interactions affecting human gene expression identified by variance association mapping

    Andrew Anand Brown, Alfonso Buil ... Richard Durbin
    Multiple replicated examples of epistasis affecting gene expression in humans are identified, some explaining a substantial proportion of the variation in expression.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

    Beatriz Navarro-Dominguez, Ching-Ho Chang ... Amanda M Larracuente
    African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
    1. Computational and Systems Biology

    Emergence and propagation of epistasis in metabolic networks

    Sergey Kryazhimskiy
    Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong, Marc A Suchard, Jesse D Bloom
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.

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