Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.

Fog signaling with a narrow morphogenetic role in Drosophila has a deeply conserved function in epithelial morphogenesis across insects.

Functional recapitulation of a likely evolutionary gain in gene expression shows that two genes are sufficient to switch mesoderm cell internalization from stochastic cell ingression to coordinated epithelial invagination.

Spatially coordinated apical constriction occurs during Drosophila salivary gland invagination, but the salivary gland can form fully internalized and elongated tubes even when this process is completely blocked.

Quantitative analysis in quasi-3D reveals apically driven cell behaviours that are closely coordinated across the tissue to allow ordered tube invagination through a focal point.

The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.

Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.

Combined optogenetic and computer modeling approaches reveal how mechanical bistability of the mesoderm epithelium works jointly with apical constriction to facilitate mesoderm invagination in Drosophila, a well-characterized model for epithelial folding.

During the morphogenesis of the tubes of the salivary glands in the fly embryo, a correct regionalization of the flat epithelial primordium by upstream transcription factors is key to drive coordinated changes in cell behavior.

Spatially and temporally patterned activation of the small GTPase Rho1 indicates that ventral-specific factors contribute to cell- and tissue-level behaviors during ventral furrow formation, the first step in Drosophila gastrulation.