293 results found
    1. Genetics and Genomics

    Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

    David A Knowles, Courtney K Burrows ... Yoav Gilad
    Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.
    1. Genetics and Genomics
    2. Neuroscience

    MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

    Michael J Lafferty, Nil Aygün ... Jason L Stein
    Inter-individual differences in miRNA expression during fetal cortical development informs genetic mechanisms for complex brain phenotypes.
    1. Genetics and Genomics
    2. Neuroscience

    Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

    Yehudit Hasin-Brumshtein, Arshad H Khan ... Desmond J Smith
    In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.
    1. Genetics and Genomics

    Population-scale proteome variation in human induced pluripotent stem cells

    Bogdan Andrei Mirauta, Daniel D Seaton ... Angus I Lamond
    Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetics of trans-regulatory variation in gene expression

    Frank Wolfgang Albert, Joshua S Bloom ... Leonid Kruglyak
    A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A conditional gene-based association framework integrating isoform-level eQTL data reveals new susceptibility genes for schizophrenia

    Xiangyi Li, Lin Jiang ... Miaoxin Li
    An improved conditional gene-based association analysis framework guided by multiple variant-gene mapping strategies was built and evaluated based on its performance in predicting the potential susceptibility isoforms, genes, and tissues of schizophrenia.
    1. Genetics and Genomics

    Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

    Eyal Ben-David, James Boocock ... Leonid Kruglyak
    The effect of genetic variation on gene expression can be specific down to the level of individual cells.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood

    Carlos Ruiz-Arenas, Carles Hernandez-Ferrer ... Mariona Bustamante
    A catalogue of associations between DNA methylation and gene expression in children will improve the interpretation of Epigenome-Wide Association Studies.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants

    Liis Kolberg, Nurlan Kerimov ... Kaur Alasoo
    Co-expression analysis combined with functional enrichment improves the detection and prioritisation of trans-eQTLs when applied to emerging cell-type-specific datasets.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

    Matteo D'Antonio, Joaquin Reyna ... Kelly A Frazer
    Analysis of the major histocompatibility complex using whole genome sequencing and RNA-seq data from hundreds of individuals provides novel insights into mechanisms underlying associations of this interval with disease.

Refine your results by:

Type
Research categories