969 results found
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

    Matthew J Shurtleff, Morayma M Temoche-Diaz ... Randy Schekman
    A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.
    1. Microbiology and Infectious Disease

    Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem

    Qian Chen, Yuyan Liu ... Taiyun Wei
    An important rice reovirus hijacks exosomes to traverse the apical plasmalemma into saliva-stored cavities in the salivary glands of insect vectors, facilitating viral horizontal transmission into rice phloem.
    1. Neuroscience

    NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

    Ruolin Zhang, Weibing Mao ... Zhiqiang Dong
    The combination of NSCs with NSC-derived exosomes ameliorated the injury of brain tissue including cerebral infarction, neuronal death, and glial scarring, and promoted the recovery of motor function.
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner, Denis V Korneev ... Rommel A Mathias
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Cell Biology

    Tetherin is an exosomal tether

    James R Edgar, Paul T Manna ... Margaret S Robinson
    Blocking acidification causes endosomes to fuse with the plasma membrane, releasing exosomes that remain attached to the cell surface via the anti-viral protein tetherin.
    1. Cell Biology
    2. Cancer Biology

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao, Lifeng Yang ... Deepak Nagrath
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Cancer Biology

    FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

    Nathalie Javidi-Sharifi, Jacqueline Martinez ... Elie Traer
    Inhibition of FGF2-FGFR1 signaling in bone marrow stroma attenuates secretion of FGF2-laden exosomes and subsequent protection of leukemia cells.
    1. Cancer Biology
    2. Cell Biology

    Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

    Karoliina Stefanius, Kelly Servage ... Kim Orth
    Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.
    1. Cell Biology
    2. Medicine

    Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo

    Sharon Elliot, Paola Catanuto ... Marilyn K Glassberg
    A systemic feature of idiopathic pulmonary fibrosis whereby urine-derived exosomes contain pro-fibrotic microRNAs and interfere with response to tissue injury.

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