905 results found
    1. Microbiology and Infectious Disease

    Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem

    Qian Chen, Yuyan Liu ... Taiyun Wei
    An important rice reovirus hijacks exosomes to traverse the apical plasmalemma into saliva-stored cavities in the salivary glands of insect vectors, facilitating viral horizontal transmission into rice phloem.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

    Matthew J Shurtleff, Morayma M Temoche-Diaz ... Randy Schekman
    A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.
    1. Neuroscience

    NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

    Ruolin Zhang, Weibing Mao ... Zhiqiang Dong
    The combination of NSCs with NSC-derived exosomes ameliorated the injury of brain tissue including cerebral infarction, neuronal death, and glial scarring, and promoted the recovery of motor function.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Cell Biology

    Tetherin is an exosomal tether

    James R Edgar, Paul T Manna ... Margaret S Robinson
    Blocking acidification causes endosomes to fuse with the plasma membrane, releasing exosomes that remain attached to the cell surface via the anti-viral protein tetherin.
    1. Cell Biology
    2. Cancer Biology

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao, Lifeng Yang ... Deepak Nagrath
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Cancer Biology
    2. Cell Biology

    Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

    Shima Ghoroghi, Benjamin Mary ... Vincent Hyenne
    A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.
    1. Cell Biology

    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

    Liang Ma, Jasleen Singh, Randy Schekman
    Mitochondria serve as a reservoir for the sorting of an miRNA into P-bodies and from there into exosomes secreted from human cultured cells.
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner, Denis V Korneev ... Rommel A Mathias
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.
    1. Cancer Biology

    FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

    Nathalie Javidi-Sharifi, Jacqueline Martinez ... Elie Traer
    Inhibition of FGF2-FGFR1 signaling in bone marrow stroma attenuates secretion of FGF2-laden exosomes and subsequent protection of leukemia cells.

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